Application effect of alfentanil in pediatric dentistry comfort diagnosis and treatment
Objective To investigate the clinical effect of alfentanil on pediatric dentistry comfort diagnosis and treatment.Methods A total of 68 children managed by dental caries treatment under general anesthesia from December 2022 to March 2023 were enrolled in the study.They were randomly assigned into remifentanil group(group R)and alfentanil group(group A),with 34 children per group.Children in both groups were treated with combined intravenous and inhalation anesthesia.Anesthesia induction and maintenance in group R were performed using remifentanil 1μg/kg and remifentanil 0.08μg·kg-1·min-1 until the end of the surgery,respectively.Anesthesia induction and maintenance in group A were performed using alfentanil 15μg/kg and alfentanil 0.375μg·kg-1·min-1 until the end of the surgery,respectively.The heart rate(HR)and mean arterial pressure(MAP)before anesthesia induction(T1),before laryngeal mask insertion(T2),after laryngeal mask insertion(T3)and at the time of placing pre-formed crowns(T4)were recorded.Operation time,respiratory recovery time after the operation,and awakening time were recorded.Intraoperative dosages of propofol and sevoflurane and fluid infusion volume were recorded.Case number of additional uses of opioid analgesics was recorded.The Face,Legs,Activity,Cry,and Consolability(FLACC)and the Steward recovery scoring system at the awakening time,and the incidence of postoperative adverse events were recorded.Results There were no significant differences in HR levels at T1-T4 time point between the two groups(P>0.05).There were no significant differences in MAP levels at T1-T3 time points between groups(P>0.05).The MAP at T4 was significantly lower in group R than that of group A,and it was significantly lower than that at T1,with a decrease by 27%(P<0.05).The respiratory recovery time of group A was significantly shorter than that of group R(P<0.05).There were no significant differences in the operation time,awakening time,intraoperative dosages of propofol and sevoflurane,intraoperative fluid infusion volume,case number of additional uses of opioid analgesics,the FLACC and Steward recovery scoring system scores at the awakening time and incidence of postoperative adverse events between groups(P>0.05).Conclusion Alfentanil can be safely used in the comfortable diagnosis and treatment of children in dental clinic,which provides a shorter respiratory recovery time and milder circulation inhibition compared with those of remifentanil.It is more conducive to the stability of intraoperative circulation.
comfortable diagnosis and treatmentalfentanilrespiratory depressionpediatric stomatology
万方数据
维普
