Changes in serum HCY and NSE levels in patients with diabetic peripheral neuropathy and their clinical significances
Objective To analyze the changes in serum homocysteine(Hcy)and neuron-specific enolase(NSE)levels in patients with diabetic peripheral neuropathy(DPN)and their clinical significances.Methods A total of 60 patients with diabetes mellitus(DM)who visited the Department of Endocrinology in our hospital from February 2020 to February 2022 were selected and grouped according to the presence of DPN or not.They were divided into experimental group 1(n=31,DM patients)and experimental group 2(n = 29,DPN patients).During the same period,a total of 30 healthy volunteers receiving physical examination were recruited in the control group.Blood glucose,serum Hcy,NSE,and nerve conduction function were detected and compared among the three groups.Spearman correlation analysis was performed to analyze the correlation of serum Hcy and NSE with blood glucose and nerve conduction function.Results The fasting plasma glucose(FPG),2-hour plasma glucose(2hPG)and hemoglobin A1C(HbA1c)of the experimental group 2 were significantly higher than those of the experimental group 1,which,in the experimental group 1 were significantly higher than those of the control group(P<0.05).Serum Hcy and NSE in experimental group 2 were significantly higher than those of experimental group 1,which,in experimental group 1 were significantly higher than those of control group(P<0.05).The sensory conduction velocity and motor conduction velocity of the motor nerve(MN),and the sensory conduction velocity and motor conduction velocity of common peroneal nerve(CPN)in the experimental group 2 were significantly lower than those of the experimental group 1,which,in the experimental group 1 were significantly lower than those of the control group(P<0.05).The F-wave latency of the MN and H-reflex latency of the CPN in the experimental group 2 were significantly higher than those of the experimental group 1,which,in the experimental group 1 were significantly lower than those of the control group(P<0.05).Hcy and NSE were positively correlated with the FPG,2hPG,HbA1c,sensory and motor conduction velocities of MN and CPN(all r>1),which were negatively correlated with the F-wave latency of the MN and H-reflex latency of the CPN(all r<1,all P<0.05).Conclusion DPN patients have higher serum Hcy and NSE levels.Their higher levels indicate severer nerve conduction dysfunction.Dynamic monitoring of serum Hcy and NSE assist the assessment of disease condition of DPN.
diabetic peripheral neuropathyhomocysteineneuron-specific enolasenerve conduction function
万方数据
维普
