Therapeutic efficacy of amoxicillin/clavulanate potassium combined with tinidazole on children with gastritis and the regulatory effect on hs-CRP,TNF-α and IL-10 levels
Therapeutic efficacy of amoxicillin/clavulanate potassium combined with tinidazole on children with gastritis and the regulatory effect on hs-CRP,TNF-α and IL-10 levels
Objective To explore the therapeutic efficacy of amoxicillin/clavulanate potassium combined with tinidazole on children with gastritis and the regulatory effect on hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor alpha(TNF-α)and interleukin 10(IL-10)levels.Methods A total of 84 children with gastritis admitted from July 2019 to July 2021 were selected.They were randomly divided into two-drug combination group and monotherapy group by double-blind control method,with 42 cases in each group.Patients in the monotherapy group were treated with amoxicillin/clavulanate potassium,and those in the two-drug combination group were treated with amoxicillin/clavulanate potassium combined with tinidazole.The clinical efficacy,serum inflammatory indexes,immune function indexes,and the incidence of adverse events were compared between the two groups.Results The total effective rate of the two-drug combination group was significantly higher than that of the monotherapy group(P<0.05).Before treatment,there were no significant differences in hs-CRP,TNF-α and IL-10 levels between the two groups(P>0.05).After treatment,serum hS-CRP and TNF-α levels in the two-drug combination group were significantly lower than those of monotherapy group,but serum IL-10 was significantly higher(P<0.05).Before treatment,there were no significant differences in CD3+,CD4+ and CD8+ levels between the two groups(P>0.05),which,after treatment,were significantly higher in the two-drug combination group than those of monotherapy group(P<0.05).The total incidence of adverse events in the two-drug combination group was significantly lower than that of the monotherapy group(P<0.05).Conclusion Amoxicillin/clavulanate potassium combined with tinidazole can improve the efficacy of children with gastritis,especially in reducing inflammation and improving immune function.It effectively reduces the risk of adverse events.
关键词
小儿胃炎/阿莫西林克拉维酸钾/替硝唑/炎性反应/免疫功能
Key words
pediatric gastritis/amoxicillin clavulanate potassium/tinidazole/inflammatory response/immune function
维普
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