Therapeutic efficacy of amoxicillin/clavulanate potassium combined with tinidazole on children with gastritis and the regulatory effect on hs-CRP,TNF-α and IL-10 levels
Objective To explore the therapeutic efficacy of amoxicillin/clavulanate potassium combined with tinidazole on children with gastritis and the regulatory effect on hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor alpha(TNF-α)and interleukin 10(IL-10)levels.Methods A total of 84 children with gastritis admitted from July 2019 to July 2021 were selected.They were randomly divided into two-drug combination group and monotherapy group by double-blind control method,with 42 cases in each group.Patients in the monotherapy group were treated with amoxicillin/clavulanate potassium,and those in the two-drug combination group were treated with amoxicillin/clavulanate potassium combined with tinidazole.The clinical efficacy,serum inflammatory indexes,immune function indexes,and the incidence of adverse events were compared between the two groups.Results The total effective rate of the two-drug combination group was significantly higher than that of the monotherapy group(P<0.05).Before treatment,there were no significant differences in hs-CRP,TNF-α and IL-10 levels between the two groups(P>0.05).After treatment,serum hS-CRP and TNF-α levels in the two-drug combination group were significantly lower than those of monotherapy group,but serum IL-10 was significantly higher(P<0.05).Before treatment,there were no significant differences in CD3+,CD4+ and CD8+ levels between the two groups(P>0.05),which,after treatment,were significantly higher in the two-drug combination group than those of monotherapy group(P<0.05).The total incidence of adverse events in the two-drug combination group was significantly lower than that of the monotherapy group(P<0.05).Conclusion Amoxicillin/clavulanate potassium combined with tinidazole can improve the efficacy of children with gastritis,especially in reducing inflammation and improving immune function.It effectively reduces the risk of adverse events.
pediatric gastritisamoxicillin clavulanate potassiumtinidazoleinflammatory responseimmune function
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