Characteristics of nerve injury in diabetic peripheral neuropathy and risk factors
Objective To explore the characteristics of nerve injury in diabetic peripheral neuropathy patients and risk factors.Methods A total of 100 patients with diabetic peripheral neuropathy who received treatment in our hospital were selected as the observation group,and 100 patients with diabetes during the same period were selected as the control group.General clinical data of the two groups were collected,and corresponding laboratory indicators were measured,including the fasting blood glucose(FBG),low-density lipoprotein cholesterol(LDL-C),glycated hemoglobin(HbA1c),urine microalbumin(MAU),triacylglycerol(TG),total cholesterol(TC),serum creatinine(Cr),serum uric acid(UA),alanine aminotransferase(ALT),aspartate aminotransferase(AST),and calculation of urinary microalbuminuria to creatinine ratio(MALB/UCr).Median nerve sensory conduction velocity(SCV),median nerve motor conduction velocity(MCV)and nerve cross-sectional area(CSA)of ulnar nerve,common peroneal nerve and tibial nerve were detected by a nerve detector.The abnormal rate of CSA in patients with different characteristics(gender,age,diabetes course,body mass index[BMI],HbA1c level)was compared.Logistic regression analysis was carried out to explore the risk factors for diabetic peripheral neuropathy.Results There were no significant differences in gender,age,BMI,FBG,MAU,TC,Cr,UA and AST between the two groups(P>0.05).There were significant differences in the course of diabetes mellitus,hypertension,vascular plaque,medication history,LDL-C,HbA1c,TG,ALT and MALB/Ucr(P<0.05).The SCV values and MCV values of ulnar nerve,common peroneal nerve and tibial nerve in observation group were significantly lower than those of control group(P<0.05),while the CSA values were significantly higher than those of control group(P<0.05).SCV and MCV were negatively correlated with CSA in the observation group(P<0.05).Logistic multiple regression analysis showed that diabetes course,LDL-C and HbA1c were independent risk factors for nerve injury in diabetic peripheral neuropathy patients.The abnormal rates of CSA of ulnar nerve,peroneal nerve and tibial nerve were significantly higher in patients with age≥60 years,diabetes course>10 years,BMI≥28kg/m2 and HbA1c level>8%(P<0.05).Conclusion Diabetes course,LDL-C and HbA1c are independent risk factors for nerve injury in patients with diabetic peripheral neuropathy,and patients with age≥60 years old,diabetes course>10 years,BMI≥28kg/m2 and HbA1c level>8%should be regularly checked for peripheral nerve injury.
万方数据
维普
