Clinical efficacy of montelukast combined with olopatadine hydrochloride tablets in the treatment of chronic urticaria and its influences on IgE levels and quality of life
Objective To observe the clinical efficacy of montelukast combined with olopatadine hydrochloride tablets on the treatment of chronic urticaria and its effect on IgE levels,quality of life,and recurrence rate.Methods A total of 88 patients with chronic urticaria were randomly divided into the control group and observation group,with 44 cases per group.Olopatadine hydrochloride tablets were given to all patients,and those in the observation group were additionally treated with montelukast.Medication was performed for 1 month.The clinical efficacy and IgE levels before and after treatment,the Dermatology Life Quality Index(DLQI),adverse events during treatment,and recurrence rate within 6 months were compared between the two groups.Results After treatment,the total effective rate of the observation group was significantly higher than that of the control group(P<0.05).The number,size,duration,frequency,itching severity score and total score of urticaria,serum IgE level,and the DLQI after treatment were all significantly reduced in the both groups than those before treatment(P<0.05),which were significantly lower in the observation group than those of the control group(P<0.05).There was no significant difference in the incidence of adverse events between groups(P>0.05).The recurrent rate at 3 and 6 months of follow-up was significantly lower in the observation group than that of the control group(P<0.05).Conclusion Montelukast combined with olopatadine hydrochloride tablets has a better clinical effect in the treatment of chronic urticaria,which can effectively reduce IgE levels,improve the quality of life,and presents a lower recurrent rate within 6 months.
chronic urticariacombination therapyantihistamineIgEquality of life
维普
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