Objective To investigate the application value of a combination detection of interleukin-6(IL-6),procalcitonin(PCT)and serum amyloid A(SAA)in diagnosing sepsis.Methods Eighty-six sepsis patients were selected as the observation group,including 32 patients in the septic shock group and 45 without septic shock in the common group.A total of 87 patients with common infection without sepsis were included in the control group.IL-6,PCT and SAA levels were detected.Their diagnostic value in sepsis patients was analyzed by the receiver operating characteristic(ROC)curve.Results IL-6,PCT and SAA levels,as well as the Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)score and the Sequential Organ Failure Assessment(SOFA)score in the observation group were significantly higher than those of the control group(P<0.05),which were significantly higher in the septic shock group than those of common group(P<0.05).The area under the curve(AUC)of IL-6,PCT and SAA alone in diagnosing sepsis was 0.763(sensitivity,75.3%;specificity,65.7%),0.787(sensitivity,70.6%;specificity,78.2%)and 0.765(sensitivity,73.45%;specificity,64.62%),respectively.The AUC of their combination detection in diagnosing sepsis was 0.931(sensitivity,91.79%;specificity,96.98%).Conclusion The combination detection of IL-6,PCT,and SAA has a certain application value for early diagnosis of sepsis,monitoring changes in the condition,and predicting the prognosis.
维普
万方数据
