N6-methyladenosine(m6A)modification affects RNA metabolism,including the stability,transport,splicing and translation at the post-transcriptional level,which controls gene expressions and participates in downstream biological effects.In recent years,it has been found that mRNAs after structural remodeling are highly regulated in the development of the central nervous system(CNS),including the disorders related with brain tissue development,abnormal proliferation and differentiation of nerve cells,and nerve injury repair.m6A modification and the dynamic balance of its relevant factors are closely related to the occurrence,development and prognosis of nervous system diseases,which can lead to CNS diseases such as cerebrovascular diseases,neurodegenerative diseases and mental diseases.This review introduces the latest research progress of m6A methylation modifiers and their interventions in cell proliferation and differentiation,and explores the role of m6A-mediated gene expressions in neural development and neurological diseases.
关键词
N6-甲基腺苷/mRNA/增殖分化/神经系统疾病/靶向治疗
Key words
N6-methyladenosine/mRNA/proliferation and differentiation/neurological diseases/targeted therapy
维普
万方数据