Immunosuppression in the tumor microenvironment(TME)can weaken the anti-tumor immunity,thus hindering the protective immune surveillance and blocking the effective anti-tumor immunity induced by cancer immunotherapy.Multiple mechanisms are involved in the immunosuppression of TME,including the involvement of multiple immune sites(e.g.,cytotoxic T-lymphocyte antigen-4[CTLA-4],programmed cell death 1[PD-1]and lymphocyte-activation gene 3[LAG-3])and immunosuppressive cells.Regulatory T(Treg)cells are a type of immunosuppressive cells that play an important role in inhibiting the anti-tumor immunity.Treg cells in the TME are closely related to the poor prognosis of colorectal cancer.Treg cells are considered as one of the main targets in immunotherapy for colorectal cancer.Therefore,elucidating the biological functions of Treg cells in cancer patients are crucial for developing optimal Treg cell-targeted immunotherapy.Here,we describe the function and phenotype of Treg cells in the TME from the perspective of Treg cell targeted immunotherapy,thus providing new ideas for immunotherapy of colorectal cancer.
regulatory T cellstumor microenvironmentimmunotherapy
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