Prognostic value of three-dimensional arterial spin labeling for long-term prognosis of acute ischemic stroke
Objective To investigate the clinical value of arterial spin labeling(ASL)in the prognosis of acute ischemic stroke(AIS).Methods Patients diagnosed with ASL in the First Hospital of Hebei Medical University were recruited as study subjects.Their relative cerebral blood flow(rCBF)was calculated.Patients were followed up by telephone contact after 3 months of onset.The prognosis was assessed by the modified Rankins Scale(mRS).The mRS scores of 0-2 points and 3-6 points suggested the good and poor prognosis,respectively.Baseline clinical data and perfusion levels were compared between the two groups.Influencing factors for the poor prognosis of AIS were analyzed by Logistic analysis.The receiver operating characteristic(ROC)curves were plotted to assess the prognostic value,and the cut-off value was calculated.Results A total of 36 AIS patients were recruited,including 20 patients in the good prognosis group and 16 in the poor prognosis group.Univariate logistic analysis of clinical and imaging data showed that the National Institutes of Health Stroke Scale(NIHSS)score on admission and perfusion level were significantly correlated with the prognosis of AIS.Multivariate logistic analysis showed that low perfusion(OR = 0.149,95％ CI:0.030-0.743,P = 0.020)was the independent risk factor for the poor prognosis of AIS.The area under the curve(AUC)of rCBF in predicting the prognosis of AIS was 0.7266(95％ CI:0.5270-0.9261,P= 0.021),and the cut-off value,sensitivity and specificity were 61.5％,95.0％ and 62.5％,respectively.Conclusion ASL effectively predicts long-term prognosis of AIS after conservative treatment.A normal perfusion in the infarcted area tends to have a good prognosis,while a low perfusion may result in a poor prognosis.Hyperperfusion in the infarcted area has no significant correlation with clinical prognosis of AIS.
万方数据
维普
