Correlation of the site and volume of acute cerebral infarction with the clinical outcome
Objective To investigate the correlation of the site and volume of acute insular infarction with the clinical outcome in elderly patients with the age of 60-70 years.Methods A total of 100 elderly patients with acute insular infarction admitted to Zhangjiakou First Hospital from February 2021 to the end of December 2021 were selected as the research subjects.The cerebral infarction sites of all subjects were screened and identified by magnetic resonance imaging(MRI),and the volume of cerebral infarction was calculated according to the Pullicino formula.Stratified by the volume size of cerebral infarction,patients were divided into group A(brain infarction volume<3cm3,n=61)and group B(brain infarction volume≥3cm3,n= 39).The National Institutes of Health Stroke Scale(NIHSS),the Montreal Cognitive Assessment(MoCA)scale,the modified Rankin Scale(mRS),the Activity of Daily Living Scale(ADL)and the Mini-Mental State Examination(MMSE)scale were used to evaluate the degree of neurological deficit,cognition,functional recovery,daily living ability and mental status at admission,at discharge and after discharge.The correlation of NIHSS,MoCA,mRS,ADL and MMSE scores with the infarct site and infarct volume was tested by rank sum test and Spearman rank correlation.Results Intragroup comparison showed that the NIHSS and mRS scores in both groups were significantly higher at admission than those at discharge,while the MoCA,ADL,MMSE scores and TST residual values at 3 and 6 months after discharge were significantly lower than at discharge(P<0.05).The inter-group comparison showed that the NIHSS and mRS scores of Group A at admission and after discharge(discharge,3 and 6 months after discharge)were significantly lower than those of group B,while the MoCA,ADL,MMSE scores and TST residual values were significantly higher(P<0.05).The residual values of TST in infarct sites(basal nucleus,cortex,brainstem,cerebellum,thalamus,mixed lesions)were significantly higher than those of group B(P<0.05).The TST residual value,NIHSS score and mRA score were negatively correlated with the cerebral infarction volume(rs=-0.358,-0.425 and-5.06,respectively;P=0.003,0.06and 0.09,respectively).The MoCA,ADL and MMSE scores were positively correlated with the cerebral infarction volume(rs=0.547,0.614 and 0.548,respectively;P<0.001).Conclusion The site of cerebral infarction in elderly patients with acute insular infarction is negatively correlated with the degree of neurological deficit and functional recovery,and positively correlated with cognition and daily living ability.The cerebral infarction volume is negatively correlated with limb motor function.
万方数据
维普
