Therapeutic efficacy analysis of probiotics combined with enteral nutrition on the type 2 diabetes mellitus complicated with pulmonary tuberculosis
Objective To explore the clinical efficacy of probiotics combined with adjuvant enteral nutrition on patients with type 2 diabetes mellitus complicated with pulmonary tuberculosis(T2DMTB).Methods A total of 77 T2DMTB patients admitted to our hospital from January 2019 to December 2020 were randomly divided into the normal diet group(Group A,19 cases),probiotics group(Group B,19 cases),enteral nutrition group(Group C,19 cases),and probiotics plus enteral nutrition group(Group D,20 cases).Conventional anti-tuberculosis and hypoglycemic therapy were applied to patients of all groups.The treatment effect among the four groups was compared,including the negative conversion rate of mycobacterium tuberculosis,changes in immune indicators and ion indicators after one month of treatment.Results There was a significant difference in the negative conversion rate of mycobacterium tuberculosis in the four groups(χ2=19.204,P= 0.0038).The negative conversion rate of group A,B,C and D was 52.63%,36.84%,57.89%and 95%,respectively.There was no significant difference in the immune level after treatment among the four groups(P>0.05).After one month of treatment,the levels of Na and P ions in group A significantly increased;the levels of Na+,Pi and Mg2+ ions in group B significantly increased;the levels of Na+,Pi,Mg2+ and Fe2+ ions in group C significantly increased;and the levels of P and Fe ions in group D significantly increased(P<0.05).Conclusion Probiotics combined with enteral nutrition can help to increase the negative conversion rate of mycobacterium tuberculosis and significantly improve the clinical treatment effect on T2DMTB patients.
type 2 diabetes mellitus complicated with pulmonary tuberculosisprobioticsenteral nutritionbacterial negative
万方数据
维普
