Effect of new whole-retina laser photocoagulation on factors related to the anterior retinal membrane in patients with proliferative diabetic retinopathy
Objective To investigate the clinical effect of new whole-retina laser photocoagulation(PRP)on the treatment of proliferative diabetic retinopathy(PDR).Methods From June 2020 to January 2022,76 eligible PDR patients were selected based on the inclusion criteria.They were randomly divided into control group and observation group according to the random number table,and then the single-blind comparative study was performed.The therapeutic effects,visual acuity,intraocular pressure and macular fovea retinal thickness(CMT)were compared between the two groups.Meanwhile,the serum levels of vascular endothelial growth factor(VEGF)and endothelin-1(ET-1)were detected and observed,and the incidence of surgical complications was statistically analyzed.Results After treatment,the total effective rate of the observation group was significantly higher than that of the control group(93.62％ vs 79.59％,χ2 =4.031,P<0.05).The visual acuity level of the observation group was significantly higher than that of the control group,and the intraocular pressure and CMT were significantly lower(P<0.05).Postoperative levels of VEGF and ET-1 in the observation group were significantly lower than those of the control group(P<0.05).The incidence of postoperative complications in the observation group was significantly lower than that of the control group(10.64％ vs 26.53％,χ2=3.977,P<0.05).Conclusion The new PRP surgery has obvious advantages in promoting the recovery of vision,intraocular pressure and macular edema and inhibiting angiogenesis in the treatment of PDR,which can further improve the clinical therapeutic effect with high safety and clinical application value.
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