Progress and breakthrough of the capture and detection of circulating tumor cells based on nanotechnology liquid biopsy
The circulation of tumor cells in peripheral blood is mostly considered as a prerequisite for cancer progression or systemic invasion.It is correlated with metastasis,which is a key event of malignancies.Circulating tumor cells(CTCs)are a biomarker for metastasis,which is a major cause of cancer deaths.Therefore,their detection and characterization are of great significance to cancer biology and clinical practice.This review describes advances and breakthroughs in nanotechnology for the capture and detection of CTCs.Nanotechnology-based liquid biopsy enables the non-invasive and dynamic analysis of molecular or cellular biomarkers,which is therefore of great significance for diagnosis,prognosis,progression,monitoring of therapeutic outcomes,understanding of disease mechanisms,and drug development.
circulating tumor cellsnanotechnologyliquid biopsyprogress and breakthrough
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