Correlation of the modified electroconvulsive therapy for depression with cytokines and C-reactive protein
Objective To investigate the changes in cytokines and C-reactive protein(CRP)levels in patients with depression before and after the treatment of modified electroconvulsive therapy(MECT)and their effects on the efficacy.Methods A total of 200 patients with depression treated from June 2021 to June 2022 were recruited.According to the different treatment methods,they were divided into the control group(100 patients)who were treated with antidepressants only,and experimental group(100 patients)who were treated with antidepressants plus MECT.CRP and interleukin(IL)levels before the treatment,and 1,2 and 4 weeks after the treatment were detected.Treatment efficacy was evaluated using the Hamilton Depression Rating Scale(HAMD).Differences in CRP and IL levels were compared between groups,and their changes before and after MECT were analyzed.Regression analysis of the therapeutic efficacy was performed.Results With the extension of treatment time,CRP,IL-1β and IL-6 levels were significantly reduced(P<0.001)and IL-4 and IL-10 were significantly enhanced in both groups(P<0.05),which were more pronounced in the experimental group than those of control group(P<0.05).The total scores of HAMD at2 and4 weeks in the experimental group were significantly lower than those of control group(P<0.001).The efficacy rate in the experimental group was significantly higher than that of control group(P<0.05).In depression patients effectively responded to MECT,the decrease value in the HAMD score presented a weak positive correlation with the change in CRP level(P<0.01),a weak positive correlation with the change in IL-1β level(P<0.001),a moderate positive correlation with the change in IL-6 level(P<0.001),a moderate negative positive correlation with the change in IL-10 level(P<0.001),and no significant correlation with the change in IL-4 level(P>0.05).The change in IL-10 significantly negatively predicted the decrease in the HAMD score,and changes in IL-6,IL-1β and CRP significantly positively predicted the decrease in the HAMD score.49.1%of the variation in the decreased HAMD score was attributed to changes in IL-10,IL-6,IL-1β and CRP(adjusted R2=0.491).Conclusion With the prolongation of treatment time,the levels of pro-inflammatory factors CRP,IL-1β and IL-6 in depression patients treated with MECT are significantly reduced,while the levels of anti-inflammatory factors IL-4 and IL-10 are significantly enhanced.Changes in IL-10,IL-6,IL-1β and CRP have certain predictive effects on the efficacy of MECT.Regulating cytokine levels and promoting neurogenesis by inhibiting immune activation explains for the efficacy of MECT on depression.
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