Correlation between the severity of coronary artery disease and renal function in hypertension patients complicated with coronary heart disease
Objective To explore the correlation between the severity of coronary artery disease and renal function in hypertension patients complicated with coronary heart disease.Methods A total of 126 hypertension patients complicated with coronary heart disease admitted to our hospital from February 2020 to July 2022 were selected as the research objects.According to the results of coronary angiography(CAG),they were divided into mild coronary artery stenosis(n= 25),moderate coronary artery stenosis(n = 56)and severe coronary artery stenosis(n = 45).The glomerular filtration rate(eGFR)of the three groups was compared.According to the Kidney Disease Quality of Life Instrument(KDQOL),patients were divided into normal renal function group(n=30),mild renal dysfunction group(n=59),and moderate-to-severe renal dysfunction group(n=37).The scores of coronary artery stenosis were compared among the three groups.The correlation of eGFR with the scores of coronary artery stenosis and the extent of coronary artery lesions was identified by Spearman correlation analysis.With the number of coronary artery lesions as the dependent variable,and age,sex,blood lipid,eGFR and other indicators as independent variables,logistic regression was performed to analyze the influencing factors for coronary artery lesions.Results There was no significant difference in the gender between patients with different degrees of coronary artery stenosis(P>0.05),but there were significant differences in the eGFR,age,smoking,body mass index(BMI),fasting blood glucose,total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)and uric acid among the three groups(P<0.05).There were significant differences in the scores of the extent of coronary artery lesions and coronary artery stenosis degree in patients with different levels of renal function(P<0.05).The eGFR was negatively correlated with the scores of coronary stenosis and extent of coronary artery lesions(r=-0.656 and-0.584,respectively,P<0.05).Logistic regression showed that age,smoking,eGFR,uric acid were independent influencing factors for coronary artery disease(P<0.05).The age over 60 years old,smoking and uric acid were independent risk factors(OR>1,P<0.05),while eGFR≥90mL/min/1.73m2 was an independent protective factor(OR<1,P<0.05).Conclusion The eGFR is negatively correlated with the severity of coronary artery disease.
hypertensioncoronary heart diseaseseverity of coronary artery diseaserenal function
万方数据
维普
