A comparative study of the effects of Ramazolam benzoate versus propofol on the incidence of postoperative delirium in elderly patients
Objective To explore the influence of Ramazolam benzoate versus propofol on the incidence of postoperative delirium in elderly patients.Methods A total of 180 elderly patients who underwent coronary artery bypass grafting surgery or valve replacement surgery from January 2021 to May 2023 were recruited as the study subjects.They were randomly assigned to the Ramazolam benzoate group(n=90)and the propofol group(n=90).Demographic information was collected.After surgery,the level of sedation was assessed every 4 hours using the Richmond Agitation and Sedation Scale(RASS).The pain and delirium were assessed using the Visual Analog Scale(VAS)and the Intensive Care Delirium Screening Checklist(ICDSC),respectively.Postoperative cognitive ability was assessed using the Montreal Cognitive Assessment(MoCA)scale.During surgery,all adverse events,including severe hypotension and respiratory depression were recorded.Results There was no significant difference in the general data between the two groups(P>0.05).The incidence of delirium on day 1,2 and 3 after surgery in the Ramazolam benzoate group was significantly lower than that of the propofol group(P<0.05).Postoperative statistics showed 13 cases of delirium in the Ramazolam benzoate group and 37 cases in the propofol group.The delirium rate in the Ramazolam benzoate group was significantly lower than that of the propofol group(14.44%vs 41.11%,P<0.05).The daily delirium severity score on day 1,2 and 3 after surgery of the Ramazolam benzoate group was significantly lower than that of the propofol group(P<0.05).The mean delirium score of the Ramazolam benzoate group was significantly lower than that of the propofol group(P<0.05).The daily MoCA score on day 1,2 and 3 after surgery of the Ramazolam benzoate group was significantly higher than that of the propofol group(P<0.05),and the mean MoCA score of the Ramazolam benzoate group was significantly higher than that of the propofol group(P<0.05).There was no significant difference in the VAS score at rest between the two groups(P>0.05).The VAS score at deep breathing or physical exercise in the Ramazolam benzoate group was significantly lower than that of the propofol group(P<0.05).There was no significant difference in the incidence of adverse events between groups(P>0.05).Conclusion Intraoperative intravenous injection of Ramazolam benzoate can significantly reduce the in-hospital incidence of delirium,alleviate the severity of delirium,and improve postoperative pain.
万方数据
维普
