Research progress of mitochondrial autophagy and NLRP3 inflammasome regulation pathway and the traditional Chinese medicine intervention
Mitochondria can selectively remove damaged mitochondria through autophagy,and ensure the function of mitochondria via controlling the quality,thus fine-tuning the number of mitochondria to maintain energy metabolism.NLRP3 inflammasome is an important component of the innate immunity,which can be activated by various types of pathogens or danger signals.It plays a crucial role in the occurrence and development of many diseases.Mitochondrial autophagy plays a negative regulatory role in the activation process of NLRP3 inflammasome by acting on many links.In recent years,traditional Chinese medicine(TCM)research on mitochondrial metabolism and regulatory pathways has been rapidly developed.Mitochondrial autophagy and NLRP3 inflammasome regulatory pathway are considered as potential and powerful targets for TCM intervention.In this paper,we mainly review the main pathways of mitochondrial autophagy and the regulatory pathways of NLRP3 inflammasome,as well as the effects of TCM on them in various diseases,aiming to provide reference for the prevention and treatment of human diseases,especially metabolic and cardiovascular diseases through regulating mitochondrial autophagy and NLRP3 inflammasome.
mitochondrial autophagyNLRP3 inflammasometraditional Chinese medicine
万方数据
维普
