Rheumatoid arthritis(RA)is a systemic inflammatory autoimmune disease characterized by synovitis and bone destruction.If it is not treated in time,it will eventually aggravate into joint deformity,dysfunction and even disability.The Janus kinase(JAK)signal transducer and activator of transcription(STAT)signaling pathway plays a key role in the occurrence and development of RA.Therapeutic targets based on the JAK/STAT signaling pathway for RA have shown the potential in relieving RA,which have been extensively analyzed in recent years.Based on the structure and function of the JAK/STAT signaling pathway,this paper explains the mechanism of the JAK/STAT signaling pathway in synovitis,cartilage and bone erosion in RA,summarizes the latest research results of basic experiments and clinical drugs on the therapeutic targets of the JAK/STAT signaling pathway,and focuses on the latest research status of 14 JAK inhibitors that have been approved worldwide.Our findings are expected to provide new ideas for the research and development of more therapeutic drugs for RA.
关键词
类风湿关节炎/JAK/STAT信号通路/治疗靶点/JAK抑制剂
Key words
rheumatoid arthritis/Janus kinase(JAK)/signal transducer and activator of transcription(STAT)signaling pathway/therapeutic targets/Janus kinase(JAK)inhibitors
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