The application value of transnasal non-invasive high-frequency oscillatory ventilation combined with transcutaneous carbon dioxide and transcutaneous oxygen monitoring in preterm infants with respiratory distress syndrome
Objective To analyze the application of transnasal non invasive high-frequency oscillatory ventilation combined with transcutaneous carbon dioxide(TcPCO2)and transcutaneous oxygen(TcPO2)monitoring in preterm infants with respiratory distress syndrome.Methods Eighty preterm infants with neonatal infant respiratory distress syndrome and treated with noninvasive respiratory support from October 2019 to October 2021 were recruited.They were randomly divided into the modified group and control group,with 40 cases per group.Patients in the modified group were managed by transnasal noninvasive high-frequency oscillatory ventilation and those in the control group were managed by transnasal continuous positive pressure ventilation.All patients were monitored by TcPCO2 and TcPO2 measurements.The pH value and TcPCO2/TcPO2 at 0,6,12 and 24h after ventilation,duration of noninvasive ventilation,conversion rate to tracheal intubation for treatment failure,incidence of complications and mortality were compared.Results There were no significant differences in pH value,TcPCO2 and TcPO2 at 0h between groups(P>0.05).Compared with those of the control group,patients in the modified group presented significantly higher pH value and TcPO2 at 6,12 and 24h,and lower TcPCO2(P<0.05).Compared with those of the control group,the duration of non-invasive ventilation and the conversion rate to mechanical ventilation for treatment failure were significantly lower in the modified group(P<0.05).There were no significant differences in the incidences of air leakage,abdominal distension,nasal injury,pulmonary hemorrhage,and infectious pneumonia between groups(P>0.05).There was no significant difference in the mortality between the control group and modified group(5.00%[2/40]vs 2.50%[1/40],P>0.05).Conclusion The application value of transnasal non-invasive high-frequency oscillatory ventilation combined with TcPCO2 and TcPO2 monitoring in preterm infants with respiratory distress syndrome is high.It can improve the respiratory function of the children and reduce the rate of mechanical ventilation by tracheal intubation,without increasing the occurrence of complications.
transnasal non-invasive high-frequency oscillatory ventilationrespiratory distress syndrome in preterm infantstranscutaneous carbon dioxide and transcutaneous oxygen monitoringcontinuous positive pressure ventilation
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