Effects of hyperbaric oxygen combined with enteral nutrition on inflammatory factors,intestinal flora and nerve function in postoperative patients with severe craniocerebral injury
Objective To explore the effect of hyperbaric oxygen combined with enteral nutrition on inflammatory factors,intestinal flora and nerve function in postoperative patients with severe craniocerebral injury.Methods From September 2021 to August 2022,totally 98 patients with severe craniocerebral injury were selected,and they were assigned and received either hyperbaric oxygen combined with parenteral nutrition(the control group,n= 49)or hyperbaric oxygen combined with enteral nutrition(the observation group,n=49).The levels of serum inflammatory factors,immune function,gastrointestinal mucosal function,intestinal flora and neurological function were compared between the two groups before and after treatment.Results After treatment,the serum levels of tumor necrosis factor-α(TNF-α),interleukin 6(IL-6)and interleukin 8(IL-8)in both groups were significantly decreased,the decrease in the observation group was more pronounced than the control group(P<0.05).Significantly increased CD3+,CD4+,CD4+/CD8+ and decreased CD8+ were found in the two groups,and which in the observation group were more obvious(P<0.05).Compared with before treatment,the levels of serum D-lactic acid,diamine oxidase(DAO)and endotoxin in the two groups decreased significantly,and the observation group was more obvious(P<0.05).After treatment,the contents of lactobacilli and bifidobacteria in the intestine of the observation group were significantly higher than those of the control group,while the contents of Escherichia coli and enterococcus were significantly lower than those of the control group(P<0.05).After treatment,the Fugel-Meyer assessment(FMA)and the Glasgow Coma Scale(GCS)scores increased and National Institutes of Health Stroke Scale(NIHSS)scores decreased significantly in both groups,and the observation group was more obvious(P<0.05).Conclusion Hyperbaric oxygen combined with enteral nutrition can alleviate inflammatory reaction,improve gastrointestinal mucosal barrier function,regulate intestinal flora imbalance,enhance immune function and promote the recovery of nerve function in postoperative patients with severe craniocerebral injury,which has important clinical application value.
hyperbaric oxygenenteral nutritionsevere craniocerebral injuryinflammatory factorsintestinal floranerve function
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