Objective To explore the early interventions of hypertensive retinopathy and its preventive and therapeutic effect on hypertension.Methods A total of 106 patients with hypertensive retinopathy who received treatment in our hospital from July 2020 to December 2021 were selected as the research subjects.They were randomly divided into the control group and observation group according to the number table method,with 53 cases in each group.Routine intervention was given to all patients,and those in the observation group were additionally given early interventions of hypertensive retinopathy.Changes in blood pressure,intraocular pressure,and visual acuity between the two groups before and after intervention were compared.The incidence of hypertension was calculated.Expression levels of vascular endothelial growth factor(VEGF)and Toll-like receptor 4(TLR4)before and after interventions were detected.The improvement of fundus lesions before and after intervention was assessed.Results After interventions,systolic blood pressure,diastolic blood pressure and incidence of hypertension in the observation group were significantly lower than those of the control group(P<0.05).The intraocular pressure in the observation group was significantly lower than that of the control group,and the visual acuity was significantly higher(P<0.05).VEGF and TLR4 levels were significantly lower in the observation group than those of the control group(P<0.05).Scores of the six clinical symptoms of fundus exudation,fundus hemorrhage,leakage,neovascularization,fluorescein angiography microaneurysm and capillary non-irrigated area in the observation group were significantly higher than those of the control group(P<0.05).Conclusion Early interventions in patients with hypertensive retinopathy can effectively control their blood pressure levels,prevent the occurrence of hypertension,reduce intraocular pressure and expression levels of VEGF and TLR4,improve vision,and promote the improvement of fundus disease symptoms.
hypertensive retinopathyearly interventionhypertensionprevention and treatment
维普
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