Objective To explore the effect of cognitive behavioral intervention combined with health education on psychological stress in patients with acute alcoholism.Methods Sixty-four patients with acute alcoholism admitted to Department of Emergency,West Branch,Affiliated Hospital of Yangzhou University were included in the study.Patients admitted to the hospital from January 1 to 31,2023,and from March 1 to 31,2023 were selected as the control group(n= 32)and the experimental group(n=32),respectively.All patients were managed by routine intervention in the emergency infusion room,and those in the experimental group received additionally cognitive behavioral intervention combined with health education.The scores of General Self Efficacy Scale(GSES),Self-rating Anxiety Scale(SAS),Self-rating Depression Scale(SDS),the Mishel Uncertainty in Illness Scale for Adults(MUIS-A),1-month,2-month,3-month follow-up of drinking frequency were included as comparators.Results After intervention,SAS and SDS scores were significantly lower in the experimental group than those in the control group(P<0.05).After intervention,GSES scores in the both groups were significantly increased(P<0.05),which increased notably in the experimental group compared with the control group(P<0.05).MUIS-A scores in the both groups were significantly decreased(P<0.05),the decrease in the experimental group was more prevalent(P<0.05).The 1-month,2-month,3-month follow-up of drinking frequency was significantly lower in the experimental group than in the control group(P<0.05).Conclusion For patients with acute alcoholism,cognitive behavioral intervention combined with health education can significantly reduce psychological stress response,improve self-efficacy,reduce uncertainty in illness and drinking frequency,and which can positively improve psychological state.It is recommended to apply and promote.