Objective To explore the clinical effect of drug-coated balloon angioplasty in the treatment of arteriovenous anastomotic fistula stenosis in uremic dialysis patients.Methods From March 2020 to March 2022,ninety-eight uremic patients with arteriovenous anastomotic fistula stenosis who underwent dialysis in our hospital were recruited in the study,and the patients were assigned into two groups according to the number table method,they received either plain old balloon angioplasty(the control group,n=49)or drug-coated balloon angioplasty(the observation group,n=49),and all patients were managed by related nursing intervention during the treatment.The incidence of postoperative complications,first-phase primary patency rate and postangioplasty restenosis rate of the two groups were statistically analyzed,and the stenosis diameter,dialysis blood flow and vascular endothelial function were compared before and after treatment.Results The incidence of postoperative complications in the observation group was significantly lower than that in the control group(P<0.05).After treatment,the stenosis diameter and dialysis blood flow in the observation group were significantly more than those in the control group(P<0.05).The levels of vascular endothelial function in the two groups were significantly decreased after treatment,which in the observation group were superior to the control group(P<0.05).The first-phase primary patency rate in the observation group was significantly higher than that of the control group,while the postangioplasty restenosis rate of follow-up was significantly lower(P<0.05).Conclusion Drug-coated balloon angioplasty in the treatment of arteriovenous anastomotic fistula stenosis in uremic dialysis patients can reduce the risk of complications,improve vascular endothelial function,expand the inner diameter of the stenosis and dialysis blood flow,and reduce the incidence of restenosis.