首页|药物涂层球囊成形术治疗尿毒症透析患者动静脉吻合口狭窄的随机对照研究

药物涂层球囊成形术治疗尿毒症透析患者动静脉吻合口狭窄的随机对照研究

Drug-coated balloon angioplasty for arteriovenous anastomotic fistula stenosis in uremic dialysis patients:A randomized controlled study

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目的 探究药物涂层球囊成形术治疗尿毒症透析患者动静脉吻合口狭窄的临床效果.方法 2020 年3 月至2022 年3 月讨透析治疗的尿毒症患者中选择98 例发生动静脉吻合口狭窄的患者作为研究对象,按数表法分为对照组和观察组,每组 49 例.对照组采用普通球囊血管成形术,观察组采用药物涂层球囊成形术治疗,治疗过程中 2组均辅以相关护理干预.统计 2 组的术后并发症发生率、一期通畅率与再狭窄率,比较治疗前后的狭窄处内径、透析血流量及血管内皮功能.结果 观察组术后并发症发生率明显低于对照组(P<0.05);观察组的狭窄处内径和透析血流量均大于对照组(P<0.05);2 组治疗后的血管内皮功能水平均下降,且观察组的各项指标水平均优于对照组(P<0.05);观察组一期通畅率高于对照组,随访期间的再狭窄率则低于对照组(P<0.05).结论 药物涂层球囊成形术治疗尿毒症透析患者动静脉吻合口狭窄可降低并发症发生风险,改善血管内皮功能,扩大狭窄处内径和透析血流量,减少再狭窄发生率.
Objective To explore the clinical effect of drug-coated balloon angioplasty in the treatment of arteriovenous anastomotic fistula stenosis in uremic dialysis patients.Methods From March 2020 to March 2022,ninety-eight uremic patients with arteriovenous anastomotic fistula stenosis who underwent dialysis in our hospital were recruited in the study,and the patients were assigned into two groups according to the number table method,they received either plain old balloon angioplasty(the control group,n=49)or drug-coated balloon angioplasty(the observation group,n=49),and all patients were managed by related nursing intervention during the treatment.The incidence of postoperative complications,first-phase primary patency rate and postangioplasty restenosis rate of the two groups were statistically analyzed,and the stenosis diameter,dialysis blood flow and vascular endothelial function were compared before and after treatment.Results The incidence of postoperative complications in the observation group was significantly lower than that in the control group(P<0.05).After treatment,the stenosis diameter and dialysis blood flow in the observation group were significantly more than those in the control group(P<0.05).The levels of vascular endothelial function in the two groups were significantly decreased after treatment,which in the observation group were superior to the control group(P<0.05).The first-phase primary patency rate in the observation group was significantly higher than that of the control group,while the postangioplasty restenosis rate of follow-up was significantly lower(P<0.05).Conclusion Drug-coated balloon angioplasty in the treatment of arteriovenous anastomotic fistula stenosis in uremic dialysis patients can reduce the risk of complications,improve vascular endothelial function,expand the inner diameter of the stenosis and dialysis blood flow,and reduce the incidence of restenosis.

drug-coated balloon angioplastyuremiadialysisarteriovenous anastomotic fistula stenosis

梅晓辉、黄路路

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226600 江苏省海安市人民医院血透室

药物涂层球囊成形术 尿毒症 透析 动静脉吻合口狭窄

海安市科技局项目

MSZ2022156

2024

河北医药
河北省医学情报研究所

河北医药

CSTPCD
影响因子:1.075
ISSN:1002-7386
年,卷(期):2024.46(5)
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