Relationship between prostaglandin E2 level and inflammatory status and vascular endothelial growth factor in patients with diabetic retinopathy
Objective To investigate the relationship between the level of prostaglandin E2(PGE2)and the inflammatory status and vascular endothelial growth factor(VEGF)in patients with diabetic retinopathy(DR).Methods From January 2021 to May 2023,totally 80 DR patients and 50 simple type 2 diabetes mellitus(T2DM)patients who were treated in our hospital were selected as the DR group and diabetes group,respectively.The patients in the DR group were divided into non-proliferative diabetic retinopathy(NPDR)group and proliferative diabetic retinopathy(PDR)group.The serum PGE2,interleukin 1β(IL-1β),tumor necrosis factor α(TNF-α)and VEGF in groups were included as comparators.Results The duration of diabetes in DR group was significantly longer than that in diabetes group,and which was significantly longer in PDR group than NPDR group(P<0.05).The levels of fasting blood glucose(FBG),hemoglobin A1c(HbA1c),IL-1β,TNF-α,VEGF and PGE2 in DR group were significantly increased than those in diabetes group(P<0.05),and which increased notably in PDR group compared with NPDR group(P<0.05).Pearson analysis showed a positive correlation between serum PGE2 levels and IL-1β,TNF-α,VEGF in DR patients(P<0.05).Logistic multiple regression showed that significantly high serum IL-1β,TNF-α,VEGF,PGE2,and significantly long duration of diabetes were risk factors for DR in T2DM patients(P<0.05).The area under the curve(AUC)for diagnosing DR with serum PGE2 was 0.808(95%CI:0.735-0.881).Conclusion For DR patients,serum PGE2 shows abnormally high expression,which can play a certain auxiliary diagnostic value.Its expression level is closely related to inflammatory status and VEGF.
万方数据
维普
