Influenza A virus infection combined with acute hemiplegia:A case report and literature review
Objective To summarize the clinical characteristics and key points of diagnosis and treatment of a case of influenza A virus(IAV)infection combined with acute hemiplegia,and to enhance the understanding of this disease through literature review.Methods The clinical manifestations,diagnosis and treatment of a case of IAV infection combined with acute hemiplegia in our department were summarized,and the relevant literature was searched.Ten previously reported cases of IAV infection combined with acute hemiplegia or cerebral infarction and 1 case in this paper were analyzed.Results A total of 11 cases of IAV infection combined with acute hemiplegia or cerebral infarction were reported,including 7 children and 4 adults.Among them,there were 4 pediatric cases in China,3 cases of viral encephalitis and 1 pediatric case of right frontal lobe and hemioval central infarction triggered by IAV infection combined with moyamoya disease.A 50-year-old female in Sudan had a right middle cerebral artery territory and cerebellum infarction caused by IAV infection.A 3-year-old girl in Australia had acute necrotizing encephalopathy.A 32-year-old female in Korea had venous infarction,which was an uncommon complication of IAV infection.There were 4 cases in Japan,including a 73-year-old male with IAV infection complicated with lacunar infarction,a 2-year-old boy with hemiconvulsion-hemiplegia-epilepsy syndrome,a 41-year-old female with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy(CADASIL),who had multiple border-zone infarcts triggered by IAV infection,and a 2-year-old girl with incontinentia pigmenti and late-onset cerebral arteriopathy induced with IAV infection.Conclusion The etiology of IAV infection combined with acute hemiplegia is complex,and influenza-associated encephalopathy/encephalitis and cerebrovascular disease should be considered.Timely imaging examination and even a genetic test may be helpful for accurate diagnosis and effective intervention.IAV infection may trigger cerebral infarction in patients with CADASIL or moyamoya disease,as well as delayed intracerebral hemorrhage in children with incontinentia pigmenti.The possible mechanism may be attributed to tissue hypoperfusion,arterial stenosis,occlusion or hemorrhage caused by original vascular lesions and cytokines storm requiring for further studies.
influenza A virushemiplegiacerebral infarctionmoyamoya disease
万方数据
维普
