Value of serum PLGF and sFlt-1 in the diagnosis and prognosis of preeclampsia in high-risk pregnant women
Objective To investigate the application value of serum placental growth factor(PLGF)and soluble vascular endothelial growth factor receptor-1(sFlt-1)on the diagnosis and prognosis of preeclampsia in high-risk pregnant women.Methods Ninety-eight cases of high-risk pregnant women who received regular obstetric examination and delivery in our hospital from June 2020 to June 2022 were enrolled.They were assigned into observation group(n=43)and control group(n=55)according to the presence or absence of preeclampsia.Patients in the observation group were divided into mild group(n=19)and severe group(n=24)according to the disease.All of these patients received the detection of serum PLGF and sFlt-1 levels,and the correlation between the indexes and the diagnosis and prognosis of preeclampsia was analyzed.Results Pregnant women in the observation group had significantly lower PLGF level,significantly higher levels of sFlt-1 and PLGF/sFlt-1 than those of the control group(all P<0.05).Pregnant women in The severe group had significantly lower PLGF level,significantly higher levels of sFlt-1 and PLGF/sFlt-1 than those of the mild group(all P<0.05).The high-risk pregnant women with neonatal asphyxia presented significantly lower PLGF level,but significantly higher levels of sFlt-1 and PLGF/sFlt-1 than those with fetal distress(P<0.05).The high-risk pregnant women with fetal distress presented significantly lower PLGF level,but significantly higher levels of sFlt-1 and PLGF/sFlt-1 than those with fetal growth restriction(P<0.05).The serum PLGF was negatively correlated with the severity of preeclampsia,while the sFlt-1 was positively correlated with the severity of preeclampsia(P<0.05).The serum PLGF was negatively correlated with the neonatal asphyxia,fetal distress,fetal growth restriction,and negatively correlated with sFlt-1(P<0.05).Conclusion Serum PLGF and sFlt-1 levels are closely related to the occurrence and development of preeclampsia.The detection of serum PLGF and sFlt-1 levels can provide reliable reference for the evaluation of diagnosis and prognosis in preeclampsia.
NETL
NSTL
万方数据
维普
