Objective To analyze the effect of ticagrelor on serum neutrophil gelatinase-associated lipocalin(NGAL)and matrix metalloproteinase-9(MMP-9)levels in postoperative patients with acute ST-segment elevation myocardial infarction(STEMI).Methods A total of 86 postoperative patients with STEMI hospitalized in our hospital from January 2020 to January 2022 were enrolled and randomized 1 ∶1 to receive either clopidogrel(clopidogrel group,n = 43)or ticagrelor(ticagrelor group,n = 43).Myocardial injury markers,serum NGAL,MMP-9 levels,thrombolysis in myocardial infarction(TIMI)blood flow grade,total incidence of major adverse cardiovascular events(MACEs)and adverse drug reactions(ADRs)were compared between the two groups.Results After treatment,the levels of serum creatine kinase isoenzyme(CK-MB),troponin I(cTnI),NGAL and MMP-9 in ticagrelor group were significantly lower than those in clopidogrel group(P<0.05).The TIMI blood flow grade in ticagrelor group was significantly better than that in clopidogrel group(P<0.05).The total incidence of MACE in ticagrelor group was significantly lower than that in clopidogrel group(2.33%vs 16.28%,P<0.05).The total incidence of MACEs in ticagrelor group was comparable to clopidogrel group(4.65%vs9.30%,P>0.05).Conclusion For postoperative patients with STEMI,ticagrelor can effectively reduce the degree of myocardial cell damage and artery stiffness,improve the blood flow grade,reduce the incidence of MACE,and it has a certain safety without obvious adverse reactions.
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