Objective To explore the clinical effect of ultrasound-guided spinal anesthesia on cesarean section in pregnancy induced hypertension(PIH)with obese.Methods A total of 80 PIH patients with obese admitted to Baoding Maternal and Child Health Hospital from January 2020 to July 2022 were randomly assigned to the research group(n=40)and the control group(n=40),in which they received ultrasound-guided spinal anesthesia and traditional landmark-guided spinal anesthesia,respectively.The puncture situation,anesthesia effects,vital signs related indicators,neonatal Apgar scores,complication were included as comparators.Results Patients in the research group presented significantly shorter duration of anesthesia preparation,anesthesia puncture,anesthesia onset,significantly less puncture times,significantly better anesthesia effects than those of the control group(P<0.05).After 10 minutes of anesthesia,patients in the research group presented significantly lower heart rate(HR),systolic blood pressure(SBP),diastolic blood pressure(DBP),significantly stable of vital signs than those of the control group(P<0.05).The neonatal Apgar scores in the research group at 1 minute,5 minutes,and 10 minutes after birth were significantly higher than those in the control group(P<0.05).The incidence of complications(nerve stimulation,epidural hemorrhage)in the research group was significantly lower than that of the control group(2.50%vs 20.00%,P<0.05,respectively).Conclusion Ultrasound-guided spinal anesthesia in cesarean section in PIH patients with obese can improve the success rate of anesthesia puncture,reduce stress response and complications,and improve the neonatal Apgar scores and anesthesia effect.