糖化血红蛋白变异指数与2型糖尿病患者中医证型的关系
Correlation between hemoglobin glycation index and traditional Chinese medicine syndromes in patients with type 2 diabetes mellitus
杨露寒 1李东海 2王冰冰 1苟文伊1
作者信息
- 1. 610041 成都市,四川省中医药科学院中医研究所四川省第二中医医院内分泌科
- 2. 610041 成都市,四川省中医药科学院中医研究所四川省第二中医医院肿瘤科
- 折叠
摘要
目的 分析糖化血红蛋白变异指数(HGI)与2型糖尿病患者中医证型的关系.方法 采用回顾性研究,利用电子病历系统选取2020年1月至2023年1月收治的175例2型糖尿病患者的临床资料,参照《中药新药临床研究指导原则》分辨患者的中医证型(阴虚热盛证,湿热困脾证,气阴两虚证,阴阳两虚,血瘀水停证,血瘀脉络证),所有患者均在末次就诊时检查糖化血红蛋白(HbA1c)、空腹血糖(FPG)水平,计算HGI,并统计患者临床指标与基线资料.比较不同证型患者HbA1c、FPG、HGI、临床指标及基线资料差异,并分析HGI与2型糖尿病患者中医证型的关系.结果 175例患者中阴虚热盛证43例(24.57％)、湿热困脾证34例(19.43％)、气阴两虚证21例(12.00％),阴阳两虚、血瘀水停证39例(22.29％)、血瘀脉络证38例(21.71％).不同证型患者HbA1c、FPG及HGI水平比较,差异有统计学意义(P＜0.05),各指标分别是血瘀脉络证＞阴阳两虚、血瘀水停证＞气阴两虚证＞湿热困脾证＞阴虚热盛证.经Spearman相关性检验显示HbA1c、FPG及HGI均与2型糖尿病中医证型存在关系(P＜0.05).结论 2型糖尿病中医证型与HGI关系密切,也与HbA1c、FPG有关.
Abstract
Objective To analyze the correlation between hemoglobin glycation index(HGI)and traditional Chinese medicine(TCM)syndromes in patients with type 2 diabetes mellitus(T2DM).Methods A retrospective study was conducted to collect the clinical data of 175 T2DM patients admitted to the hospital from January 2020 to January 2023 using the electronic medical record system.The patient's TCM syndrome type was identified to Yin deficiency and heat syndrome,damp-heat trapping spleen syndrome,Qi and Yin deficiency syndrome,yin and yang deficiency syndrome,blood stasis and water stopping syndrome,blood stasis syndrome referred to the'Guiding Principles of Clinical Research on New Drugs of Chinese Medicines'.All patients were examined for glycated hemoglobin(HbAlc)and fasting blood glucose(FPG)levels at the last visit,HGI level of the patients was calculated,and clinical indicators and baseline data of patients were counted.The differences of HbAlc,FPG,HGI,clinical indexes and baseline data of patients with different syndromes were compared,and the correlation between HGI and TCM syndromes in patients with T2DM was analyzed.Results Among the 175 patients,there were 43 cases(24.57％)of yin deficiency and heat syndrome,34 cases(19.43％)of damp-heat trapping spleen syndrome,21 cases(12.00％)of Qi and Yin deficiency syndrome,39 cases(22.29％)of yin and yang deficiency syndrome,and blood stasis and water stopping syndrome,and 38 cases(21.71％)of blood stasis syndrome.There were statistically significant differences in HbAlc,FPG and HGI levels among patients with different syndrome types(P＜0.05).The indexes were blood stasis syndrome＞yin and yang deficiency syndrome,blood stasis and water stopping syndrome＞Qi and yin deficiency syndrome＞damp-heat trapping spleen syndrome＞yin deficiency and heat syndrome.Spearman correlation test showed that HbAlc,FPG and HGI were all related to the TCM syndromes of T2DM(P＜0.05).Conclusion The TCM syndromes of T2DM are closely related to HGI,also to HbAlc and FPG.
关键词
糖化血红蛋白/2型糖尿病/中医证型/相关性Key words
glycosylated hemoglobin/type 2 diabetes mellitus/traditional Chinese medicine syndrome/correlation引用本文复制引用
基金项目
四川省中医药局科学技术研究专项任务书项目(2020JC0113)
出版年
2024
NETL
NSTL
维普
万方数据