Effect of budesonide combined with terbutaline and atomization inhalation of ipratropium bromide on the treatment of bronchopneumonia in children
Objective To explore the effect of budesonide combined with terbutaline and atomization inhalation of ipratropium bromide on children with bronchopneumonia.Methods Totally 84 children with bronchopneumonia admitted to our hospital from May 2021 to May 2022 were selected for the study.They were randomly divided into control group and observation group,with 42 cases per group.Patients in the both groups were treated with budesonide combined with terbutaline,and those in the observation group were additionally treated with atomization inhalation of ipratropium bromide.The inflammatory factors,symptom improvement time and incidence of adverse events were compared between the two groups.Results There were no significant differences in pre-treatment inflammatory factors between groups(P＞0.05).After treatment,tumor necrosis factor-alpha(TNF-α)([3.12±0.65]pg/L),interleukin-10(IL-10)([4.21±1.52]μg/L)and interleukin-6(IL-6)([3.68±1.12]pg/L)levels in the observation group were significantly lower than those of control group(P＜0.05).The time for temperature recovery([3.12±0.35]d),absence of cough([3.05±1.21]d),absence of asthma([2.72±1.05]d),absence of pulmonary rales([2.02±0.65]d)and absence of shadows on X-ray scans([4.78± 0.23]d)was significantly shorter in the observation group than that of control group(P＜0.05).Respiratory factors before treatment were comparable between groups(P＞0.05).After treatment,forced vital capacity(FVC,[3.12±0.13]L),forced expiratory volume in 1 s(FEV1,[2.99±0.35]L)and peak expiratory flow(PEF,[3.99±0.65]L/s)were significantly higher in the observation group than those of control group(P＜0.05).The incidence of adverse events was significantly lower in the observation group than that of control group(4.76％vs 23.81％,P＜0.05).Conclusion Budesonide combined with terbutaline and atomization inhalation of ipratropium bromide has a significant effect on the treatment of bronchopneumonia in children,which significantly reduces the level of body inflammation,shortens the time for symptom improvement and prevents adverse reactions.It can be used for reference and promotion in clinical practice.
budesonideterbutalineatomization inhalation of ipratropium bromidebronchopneumoniarespiratory function
NETL
NSTL
万方数据
维普
