Esketamine is the pure enantiomer of racemic ketamine,with higher affinity for N-methyl-D-aspartate(NMDA)receptors and p-opioid receptors.It possesses stronger sedative,analgesic,and antidepressant effects,with rapid onset and elimination.It has a weak respiratory depressive effect and can mildly stimulate the cardiovascular system.It can also dilate the bronchi and bronchioles.Esketamine has a low incidence of adverse reactions and is widely used in the field of mental illness and clinical anesthesia.This article provides a comprehensive review of its clinical applications and adverse reactions,aiming to provide references and guidance for the medical use of esketamine.
NETL
NSTL
万方数据
维普
