艾司氯胺酮的临床应用进展
Advance of esketamine in clinical application
田春林 1涂青梅 2陈好亮 3田刚3
作者信息
- 1. 443000 湖北省宜昌市,三峡大学附属仁和医院
- 2. 湖北医药学院附属太和医院
- 3. 湖北医药学院附属人民医院
- 折叠
摘要
艾司氯胺酮是氯胺酮的纯右旋同分异构体,与谷氨酸N-甲基-D-天冬氨酸受体和μ阿片受体亲和力更高,具有更强的镇静、镇痛、抗抑郁等作用,并且起效和消除迅速,抑制呼吸作用弱,可轻微兴奋循环系统,可扩张气管及支气管,不良反应发生率低,在精神疾病领域和临床麻醉应用广泛.本文对其临床应用及不良反应进行综述,以期为艾司氯胺酮在医疗使用中提供借鉴和参考.
Abstract
Esketamine is the pure enantiomer of racemic ketamine,with higher affinity for N-methyl-D-aspartate(NMDA)receptors and p-opioid receptors.It possesses stronger sedative,analgesic,and antidepressant effects,with rapid onset and elimination.It has a weak respiratory depressive effect and can mildly stimulate the cardiovascular system.It can also dilate the bronchi and bronchioles.Esketamine has a low incidence of adverse reactions and is widely used in the field of mental illness and clinical anesthesia.This article provides a comprehensive review of its clinical applications and adverse reactions,aiming to provide references and guidance for the medical use of esketamine.
关键词
艾司氯胺酮/临床应用/麻醉/抗抑郁/术后认知功能障碍Key words
esketamine/clinical application/anesthesia/antidepressant/postoperative cognitive dysfunction引用本文复制引用
基金项目
湖北省自然科学基金(2014CFC1150)
出版年
2024
NETL
NSTL
维普
万方数据