EGFR基因突变对宫颈癌容积旋转调强放疗的效果及预后的影响
Effect of EGFR gene mutation on clinical efficacy and prognosis of cervical cancer treated by rotational volumetric-modulated arc therapy
陈建1
作者信息
- 1. 234000 安徽省宿州市,皖北煤电集团总医院放疗二科
- 折叠
摘要
目的 分析表皮生长因子受体(EGFR)基因突变对宫颈癌容积旋转调强放疗的临床疗效及预后的影响.方法 选取2019～2021 年收治的EGFR基因突变宫颈癌患者50 例为研究组,另选取EGFR基因未突变宫颈癌患者 50 例为对照组,2 组均行容积旋转调强放疗治疗.对比 2 组临床疗效、免疫功能、肿瘤标志物、基质金属蛋白酶、生长因子水平及预后情况.结果 与对照组相比,研究组患者客观缓解率、疾病控制率较高,6 个月生存率、1 年生存率较高(P<0.05).治疗后,2 组患者CD3+、CD4+、CD4+/CD8+水平降低,但与对照组比较研究组较高,CD8+水平升高,但与对照组比较研究组较低(P<0.05).治疗后,2 组患者糖类抗原 125(CA125)、鳞状细胞癌抗原(SCC-Ag)、癌胚抗原(CEA)、基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶-9(MMP-9)、血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)水平降低,且与对照组比较研究组较低(P<0.05).结论 EGFR基因突变可提升容积旋转调强放疗治疗宫颈癌的临床疗效,且可改善患者预后情况,提升生存率.
Abstract
Objective To analyze the effect of epidermal growth factor receptor(EGFR)gene mutation on the clinical efficacy and prognosis of cervical cancer treated by rotational volumetric-modulated arc therapy(VMAT).Methods Fifty cervical cancer patients with EGFR gene mutations admitted in our hospital from January 2019 to December 2021 were enrolled in the study group,and 50 cervical cancer patients without EGFR gene mutations during the same period were included in the control group.Patients in both groups were treated with rotational VMAT.The clinical efficacy,immune function,tumor markers,matrix metalloproteinases(MMPs),growth factor levels and prognosis of the two groups were detected and compared.Results Compared with those of the control group,the objective response rate,disease control rate,6-month survival and 1-year survival were significantly higher in the study group(P<0.05).After treatment,decreased levels of CD3+,CD4+and CD4+/CD8+,and increased CD8+were detected in both groups,which were significantly pronounced in the study group than those of control group(P<0.05).After treatment,decreased levels of carbohydrate antigen 125(CA125),squamous cell carcinoma antigen(SCC-Ag),carcinoembryonic antigen(CEA),matrix metalloproteinase-2(MMP-2),matrix metalloproteinase-9(MMP-9),vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF)were detected in both groups,which were significantly pronounced in the study group than those of control group(P<0.05).Conclusion EGFR gene mutation can improve the clinical efficacy of rotational VMAT on cervical cancer,as well as the prognosis and survival rate.
关键词
表皮生长因子受体/容积旋转调强放疗/宫颈癌/治疗结果/预后Key words
epidermal growth factor receptor/rotational volumetric-modulated arc therapy/cervical cancer/clinical effect/prognosis引用本文复制引用
基金项目
国家自然科学基金面上项目(61976008)
出版年
2024
NETL
NSTL
万方数据