Effect of EGFR gene mutation on clinical efficacy and prognosis of cervical cancer treated by rotational volumetric-modulated arc therapy
Objective To analyze the effect of epidermal growth factor receptor(EGFR)gene mutation on the clinical efficacy and prognosis of cervical cancer treated by rotational volumetric-modulated arc therapy(VMAT).Methods Fifty cervical cancer patients with EGFR gene mutations admitted in our hospital from January 2019 to December 2021 were enrolled in the study group,and 50 cervical cancer patients without EGFR gene mutations during the same period were included in the control group.Patients in both groups were treated with rotational VMAT.The clinical efficacy,immune function,tumor markers,matrix metalloproteinases(MMPs),growth factor levels and prognosis of the two groups were detected and compared.Results Compared with those of the control group,the objective response rate,disease control rate,6-month survival and 1-year survival were significantly higher in the study group(P<0.05).After treatment,decreased levels of CD3+,CD4+and CD4+/CD8+,and increased CD8+were detected in both groups,which were significantly pronounced in the study group than those of control group(P<0.05).After treatment,decreased levels of carbohydrate antigen 125(CA125),squamous cell carcinoma antigen(SCC-Ag),carcinoembryonic antigen(CEA),matrix metalloproteinase-2(MMP-2),matrix metalloproteinase-9(MMP-9),vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF)were detected in both groups,which were significantly pronounced in the study group than those of control group(P<0.05).Conclusion EGFR gene mutation can improve the clinical efficacy of rotational VMAT on cervical cancer,as well as the prognosis and survival rate.
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