Characteristics of gut microbiota in patients with Hashimoto's thyroiditis and goiter
Objective To investigate the correlation of Hashimoto's thyroiditis(HT)and goiter with the distribution and abundance of gut microbiota.Methods Thirty-one clinical stool samples were collected,including 10 healthy subjects(group A),9 patients with HT and goiter(group B),and 12 with HT but without goiter(group C).The 16S ribosomal RNA(rRNA)gene sequencing assays were performed to characterize the gut microbiota.Results A total of 16,941 operational taxonomic units(OTUs)were clustered in the three groups.The distribution of OUT composition in group A was relatively concentrated,and the diversity of gut microbiota in group B and C decreased,but there was no significant difference among the three groups(P>0.05).At the family level,the abundance of Bacteroidaceae in group B was significantly lower than that in group A and C,while the abundances of Prevotellaceae and Veillonellaceae were significantly higher(P<0.05).At the genus level,the abundance of Bacteroidaceae in group B was significantly lower than that of group A and C,while the abundance of Prevotella was significantly higher(P<0.05).Conclusion Patients with HT and goiter have altered distribution and abundance of gut microbiota,with an imbalance in it.Bacteroidaceae,Bacteroides,Prevotellaceae,Veillonellaceae and Prevotella may be biomarkers to distinguishing HT with goiter.
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