Objective To explore the diagnostic value of multi-slice spiral CT(MSCT)combined with serum soluble B7-H4(sB7-H4)and chitinase-3-like protein 1(YKL-40)for lymph node metastasis of gastric cancer.Methods A total of 114 gastric cancer patients diagnosed in our hospital from January 2021 to January 2023 were enrolled.They were grouped into a metastatic group(n=54)and a non metastatic group(n=60)based on whether the presence or absence of lymph node metastasis.All patients were managed by multi-slice spiral computed tomography(MSCT)examinations,the serum levels of sB7-H4 and YKL-40 were detected by enzyme linked immunosorbent assay(ELISA),the receiver operating characteristic(ROC)curve was performed to analyze the diagnostic value of serum sB7-H4 and YKL-40 levels in lymph node metastasis of gastric cancer,the consistency between test methods with pathological results was evaluated by Kappa consistency test.Results The levels of serum sB7-H4 and YKL-40 in metastatic group were obviously higher than those in non metastatic group(P<0.05).The area under the curve(AUC)for diagnosing lymph node metastasis in gastric cancer by serum sB7-H4 and YKL-40 levels was 0.794 and 0.811,respectively.The consistency between MSCT,sB7-H4,and YKL-40 alone,and their combined examination with pathological results was high,moderate,moderate,and extremely high,respectively,with Kappa value of 0.721,0.473,0.408,and 0.859,respectively(P<0.05).The specificity and positive predictive value of MSCT combined with serum sB7-H4 and YKL-40 in diagnosing lymph node metastasis of gastric cancer were obviously higher than those of the three diagnostic methods alone,the accuracy and negative predictive value were obviously higher than those of serum sB7-H4 and YKL-40 for individual diagnosis,while the sensitivity was obviously higher than that of serum sB7-H4 for individual diagnosis(P<0.05).Conclusion The combination of MSCT with serum sB7-H4 and YKL-40 has high practical value in the diagnosis of lymph node metastasis in gastric cancer.
gastric cancerlymph node metastasismulti-slice spiral computed tomographysoluble B7-H4chitinase-3-like protein 1
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