Effect of an early application of human immunoglobulin combined with interferon on T lymphocyte subsets levels in children with severe hand-foot-mouth disease
Objective To explore the efficacy of an early application of human immunoglobulin combined with interferon on T lymphocyte subsets levels in children with severe hand-foot-mouth disease(HFMD).Methods A total of 100 children with severe HFMD admitted from June 2018 to June 2020 were enrolled.They were divided into the control group(50 cases)and observation group(50 cases)based on disease severity.Children in both groups were treated with inhaled nebulised interferon,and those in the observation group were additionally given human immunoglobulin.The clinical efficacy,time of symptom improvement,inflammatory factor,and T lymphocyte subsets levels were compared.Results After treatment,the total clinical efficacy of the observation group was significantly higher than that of control group(94.00%vs 70.00%,P<0.05).Length of stay,time to blood pressure recovery and heart rate recovery,time to peripheral circulation improvement in the observation group were significantly shorter than those of control group(P<0.05).The interleukin 2(IL-2),IL-6,IL-10 and tumour necrosis factor alpha(TNF-α)levels in the observation group were significantly lower than those of the control group(P<0.05),and the levels of CD3+,CD4+,CD8+and CD4+/CD8+in the observation group were significantly better than those of the control group(P<0.05).Conclusion Human immunoglobulin combined with interferon effectively alleviate inflammatory response,enhance T lymphocyte subsets,improve immune function and accelerate the recovery of children with severe HFMD.
severe hand-foot-mouth diseasehuman immunoglobulininterferonT lymphocyte subsetsinflammatory factors
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