首页|胃息肉合并肠息肉发生相关危险因素及病理特征分析

胃息肉合并肠息肉发生相关危险因素及病理特征分析

Analysis of related risk factors and pathological features of gastric polyps complicated with intestinal polyps

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目的 分析胃息肉合并肠息肉发生的相关危险因素及与其病理特征的相关性,以期为高风险人群内镜检查的选择、相关防治措施的制定和医疗资源的节约提供一些依据.方法 收集2021 年1 月至2022 年5 月消化内科经胃镜和结肠镜检查发现的胃息肉合并肠息肉患者 100 例作为病例组,结肠镜检查发现的 100 例单纯肠息肉患者为对照组,收集患者相关资料,比较 2 组患者间相关资料的差异性,分析胃息肉合并肠息肉发生的高危因素及与其病理特征的相关性.结果 2 组患者性别、年龄、体重指数(BMI)、生活史、胆系疾病史、脂肪肝、高三酰甘油血症、高胆固醇血症、高尿酸血症、癌胚抗原(CEA)升高、糖类抗原(CA199)升高和CA125 升高无统计学意义(P>0.05).病例组患者幽门螺杆菌(H.Pylori)感染率高于对照组(P<0.05).2 组患者在息肉数目、发生部位、息肉直径和病理类型比较差异无统计学意义(P>0.05).胃息肉合并肠息肉发生特点与危险因素间的关系分析发现:多发性息肉患者在年龄≥60 岁、H.Pylori感染、吸烟史、饮酒史和高CA199 较单发性息肉患者比较,差异有统计学意义(P<0.05);息肉直径<10 mm患者在H.Pylori感染情况方面较息肉直径>10 mm患者比较差异有统计学意义(P<0.05);腺瘤性息肉患者在H.Pylori感染情况和CA199 升高方面较非腺瘤性息肉差异有统计学意义(P<0.05).结论 胃息肉合并肠息肉发生的主要危险因素为H.Pylori感染,患者息肉病理特征与高龄、H.Pylori感染、吸烟、饮酒和CA199 水平间有一定相关性,应注意进行H.Pylori感染根治治疗、改善生活习惯、定期进行肿瘤标志物筛查和内镜检查,以便早期发现病变和进行干预.
Objective To analyze the related risk factors and pathological features of gastric polyps complicated with intestinal polyps,thus providing basis for the selection of endoscopic examination,the formulation of relevant prophylactic-therapeutic measures,and the conservation of medical resources in high-risk people.Methods One hundred patients with gastric polyps complicated with intestinal polyps diagnosed by gastroscopy and colonoscopy in the department of gastroenterology of our hospital from January 2021 to may 2022 were enrolled(the case group),and 100 patients with simple intestinal polyps diagnosed by colonoscopy were selected(the control group).Relevant data of patients were collected and recorded.Correlation between high-risk factors and pathological features in patients with gastric polyps complicated with intestinal polyps was analyzed by comparing the differences in relevant data.Results There was no significant difference in gender,age,body mass index(BMI),life history,history of biliary diseases,fatty liver,hypertriglyceridemia,hypercholesterolemia,hyperuricemia,elevated carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA199)and cancer antigen 125(CA125)between the two groups(P>0.05).The infection rate of helicobacter pylori(H.Pylori)in the case group was significantly higher than that of the control group(P<0.05).There was no significant difference in the number,location,diameter and pathological type of polyps between groups(P>0.05).The result from the correlation between the pathological characteristics and high-risk factors indicated that patients with multiple polyps had statistical significance in terms of age≥60 years,H.Pylori infection,smoking history,drinking history and high CA199 compared with those with single polyps(P<0.05).The H.Pylori infection of patients with polyp diameter<10mm was statistically significant compared with those with polyp diameter>10mm(P<0.05).Patients with adenomatous polyps had statistical significance in H.Pylori infection and CA199 increase relative to those with non-adenomatous polyps(P<0.05).Conclusion The main risk factor of gastric polyps complicated with intestinal polyps is H.Pylori infection,and their pathological characteristics are associated with old age,H.Pylori infection,smoking,drinking and CA199 level.Therefore,the eradication of H.pylori,improvement of living habits,regular screening of tumor markers,and endoscopy should be carried out to detect lesions and intervene early.

gastric polyps complicated with intestinal polypsrisk factorspathological features

王国英、曹志荣、赵靖、戴铭、杨珺

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213300 江苏省溧阳市人民医院消化内科

胃息肉合并肠息肉 危险因素 病理特征

溧阳市人民医院科技项目

2021YJKT005

2024

河北医药
河北省医学情报研究所

河北医药

CSTPCD
影响因子:1.075
ISSN:1002-7386
年,卷(期):2024.46(9)
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