Objective To investigate the analgesic effect of parecoxib sodium combined with sufentanil after laparoscopic radical nephrectomy and its effect on immune function.Methods A total of 64 patients with advanced renal cell carcinoma who were treated with laparoscopic radical nephrectomy from February 2018 to June 2019 were randomly divided into control group and study group,with 32 cases in each group.Intravenous injection of parecoxib sodium,and normal saline 30 minutes before the induction of anesthesia was given to patients of study group and control group,respectively.Sufentanil administration using the patient-controlled analgesia pump was immediately given after waking up.The visual analogue Scale(VAS)score and the Numerical Rating Scale(NRS)scores before(T0)and 6h(T1),12h(T2),24h(T3)and 48h(T4)after postoperative analgesia were compared between the two groups.In addition,hemodynamic indicators(heart rate[HR],mean arterial pressure[MAP])at T0 and T4,and immune function-related indicators(CD3+,CD4+,CD8+,CD4+/CD8+)at T0 and T4 were compared between groups.Adverse events were recorded.Results There were significant differences in the main effects of the VAS score,NRS score and time between groups(all P<0.05),and a time×group interaction existed(P<0.05).There were no significant differences in HR and MAP at T0 between the two groups(P>0.05).Compared with those at T0,HR and MAP at T4 in both groups were significantly lower(P<0.05),which were significantly lower in the study group than those in control group(P<0.05).There were no significant differences in the CD3+,CD4+and CD4+/CD8+at T0 between groups(all P>0.05).At T4,CD3+,CD4+in the study group were significantly higher than those in the control group(all P<0.05).There was no significant difference in the incidence of adverse events within 48 h of medications between groups(P>0.05).Conclusion Parecoxib sodium combined with sufentanil for postoperative analgesia in patients undergoing laparoscopic radical nephrectomy can achieve a good effect of postoperative analgesia,effectively improve the postoperative immune function,and with high safety.It is worthy of clinical promotion.
parecoxib sodiumsufentanilkidney cancerlaparoscopic surgeryanalgesiaimmune function
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