超声诊断胎儿鼻骨异常的相关性研究
Correlation study of ultrasonographic diagnosis of fetal nasal bone abnormalities
朱泽阳 1张艳 1孙小平1
作者信息
摘要
目的 研究产前超声诊断胎儿鼻骨异常与先天性结构畸形和染色体非整倍体异常的相关性.方法 选取 2019 年 2 月至 2022 年 4 月孕期检测胎儿鼻骨发育异常胎儿 262 例,2018 年 7 月至 2022 年 4 月羊水穿刺结果染色体异常胎儿 170 例,均采用彩色多普勒超声诊断仪对其进行产前超声检查,分析胎儿鼻骨异常合并畸形情况、单纯鼻骨发育异常的胎儿染色体异常发生情况、鼻骨异常合并畸形的胎儿染色体异常发生情况.结果 262 例鼻骨发育异常胎儿中,单纯鼻骨异常 140 例,合并畸形 122 例,合并畸形率为 46.6%.122 例鼻骨发育不良胎儿合并结构畸形者中,单发畸形 83 例(76.3%),多发畸形 39 例(23.7%).170 例羊水穿刺染色体异常胎儿中,合并鼻骨发育异常 75例,占 44.1%,鼻骨发育正常 95 例,占 55.9%.结论 鼻骨发育异常合并胎儿结构畸形、胎儿的染色体异常发生率显著.妊娠期超声检查胎儿鼻骨发育,可提高胎儿先天异常检出率.
Abstract
Objective To study the correlation of prenatal ultrasonographic diagnosis of fetal nasal bone abnormalities with congenital structural malformations and aneuploidy abnormalities of chromosomes.Methods A total of 262 fetuses with abnormal fetal nasal bone development detected during pregnancy from February 2019 to April 2022,and 170 fetuses with aneuploidy abnormalities of chromosomes detected by amniocentesis in our hospital from July 2018 to April 2022 were recruited.All fetuses were examined by Color Doppler ultrasonography during the prenatal ultrasound examination.The occurrence of fetal nasal bone abnormalities combined with malformations,and chromosomal abnormalities in fetuses with abnormal nasal bone development and those with abnormal nasal bone development combined with malformations were analyzed.Results Of the262 fetuses with nasal bone abnormalities,140 had nasal bone abnormalities and 122(46.6%)combined with malformations.Of the 122 fetuses with structural malformations of nasal bone,83(76.3%)had a single malformation and 39(23.7%)had multiple malformations.Of 170 fetuses with chromosomal abnormalities detected by amniocentesis,75(44.1%)had abnormal nasal bone development and 95(55.9%)had normal nasal bone development.Conclusion The incidence of fetal nasal bone abnormalities combined with structural malformations or chromosomal abnormalities is high;Ultrasonographic examination of fetal nasal bone development during pregnancy contributes to enhance the detection rate of fetal congenital abnormalities.
关键词
产前超声胎儿鼻骨异常/鼻骨缺失/鼻骨发育不良/结构畸形/染色体非整倍体异常Key words
prenatal ultrasonographic diagnosis of fetal nasal bone abnormalities/nasal bone defects/nasal bone hypoplasia/structural malformations/aneuploidy abnormalities of chromosomes引用本文复制引用
出版年
2024
NETL
NSTL
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