Objective To explore the effect of ketoacidosis(DKA)at varying degrees on executive function in children with type 1 diabetes mellitus(T1DM)based on the Wisconsin card sorting test(WCST).Methods A total of 118 children with DKA hospitalized in First Hospital of Qinhuangdao from March 2017 to September 2022 were included.According to the severity of DKA,they were divided into mild group(n=37),moderate group(n=40)and severe group(n=41).Another 36 newly diagnosed T1DM children without DKA were selected as control group.General data were collected.WCST was used to evaluate executive ability,and Chinese version of the Wechsler Intelligence Scale for Children(C-WISC)was used to evaluate cognitive function.Results Compared with those of the control group,children in DKA group presented significantly higher random blood glucose and lower pH and HCO3 levels(P＜0.05).The numbers of completed classification and conceptual level were significantly lower,and the numbers of wrong answers,persistent errors and persistent answers were significantly higher in children of DKA group(P＜0.05).The classification,knowledge,arithmetic,comprehension,vocabulary,mapping,picture arrangement,building blocks,graphic mosaic,coding and verbal IQ were significantly higher,and operation intelligence quotient and total intelligence quotient were significantly lower,which were correlated with the degree of DKA(P＜0.05).Executive function was positively correlated with cognitive function(r=0.698,P＜0.05).Conclusion DKA can cause executive dysfunction in children with T1DM,and the damage is more obvious with the aggravation of the disease.There is a significant correlation between executive function and cognitive function in T1DM children.
type 1 diabetes mellitusdiabetic ketoacidosisWisconsin card sorting testperforming functioncognitive functionchildren
NETL
NSTL
万方数据
