首页|PD-1抑制剂在晚期胃癌治疗的研究进展

PD-1抑制剂在晚期胃癌治疗的研究进展

Progress of PD-1 inhibitor in the treatment of advanced gastric cancer

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中国是胃癌的高发国家,多数患者确诊时已逐步发展局部进展期或晚期,而晚期胃癌作为我国胃癌治疗领域所无法避免的一大难题,始终缺乏有效的治疗手段.随着程序性死亡受体 1(PD-1)或程序性死亡受体配体 1(PD-L1)单克隆抗体的问世,研究发现其能有效提高晚期胃癌患者的总生存率,因而在世界范围胃癌治疗领域掀起了免疫研究热潮.本文就PD-1抑制剂的作用机制、临床免疫疗效、不良反应等方面的进展进行综述.
China is a high-incidence country of gastric cancer(GC),most patients have been diagnosed when the development of local progression or advanced stage,and advanced GC as our country's treatment field can not avoid a major problem,there is always a lack of effective treatment.With the advent of programmed death receptor 1(PD-1)or programmed death receptor ligand 1(PD-L1)monoclonal antibody,that it can effectively improve the overall survival rate of patients with advanced GC have been found.Therefore,there is a great upsurge of immunologic research for GC worldwide.This article reviews the progress of PD-1 inhibitors in the mechanism of action,clinical immunotherapeutic efficacy,adverse reactions and so on.

gastric cancerimmunotherapyprogrammed death receptor 1(PD-1)inhibitor

许威、阎龙、杨佳兴、许淑梅、吴金玲、范瑞芳

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730050 兰州市,中国人民解放军联勤保障部队第九四〇医院普通外科

胃癌 免疫治疗 PD-1抑制剂

甘肃省青年科技项目甘肃省自然科学基金军队后勤科研计划

22JR11RA00221JR1RA18620BJZ23

2024

河北医药
河北省医学情报研究所

河北医药

CSTPCD
影响因子:1.075
ISSN:1002-7386
年,卷(期):2024.46(10)
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