Association between CDH1 single nucleotide polymorphism and clinical prognosis of epithelial ovarian cancer
Objective To explore the association of the E-cadherin gene(CDH1)single nucleotide polymorphisms(SNPs)of 160C/A,-347G/GA and 3'UTR+54C/T with the clinical prognosis of epithelial ovarian cancer patients(EOC).Methods The genotype distribution of-160C/A,-347G/GA and 3'UTR+54C/T genetic polymorphisms in the CDH1 gene promoter region in 412 EOC patients was detected by polymerase chain reaction(PCR).Results The logistic regression indicated that age,International Federation of Gynecology and Obstetrics(FIGO)staging,and tumor residual size were related to the 5-year clinical outcomes of EOC patients(P<0.05).The age and FIGO staging were associated with 3-year clinical prognosis,while the residual tumor size was only associated with 3-year recurrence.K-M survival analysis showed that CDH1-347 GA/GA polymorphism was correlated with 5-year prognosis of EOC patients.EOC patients carrying GA/GA genotype had a significantly shorter median progression-free survival(PFS)and overall survival(OS)compared with those carrying the G/G CDH1 genotype,followed by EOC patients carrying GA/GA genotype.Cox multivariate regression demonstrated that,after adjusting for prognostic factors(age,FIGO staging,and tumor residual size),EOC patients carrying the GA/GA CDH1 genotype had higher risks of recurrence(Hr=2.50;95%CI=1.51-4.13)and death(Hr=2.50;95%CI=1.51-4.14)compared with those carrying the G/G genotype.Conclusion CDH1-347 GA/GA SNP is significantly associated with the clinical prognosis of EOC.CDH1-347 GA/GA SNP may be a biomarker for clinical prognosis of EOC.
万方数据
维普
