Objective To study the correlation of serum amyloid A(SAA),C-reactive protein(CRP),neutrophil to lymphocyte ratio(NLR),and platelet to lymphocyte ratio(PLR)with disease progression and humoral immunity in children infected with mycoplasma pneumoniae.Methods From September 2021 to September 2023,120 children with mycoplasma pneumoniae pneumonia admitted to our hospital were used as the case group,and 128 healthy children who underwent physical examination in our hospital during the same period were used as the healthy control group.Serum SAA,CRP,peripheral NLR,PLR and humoral immunity parameters of the two groups were compared.According to the severity of the disease,children in the case group were divided into the mild group(74 cases)and severe group(46 cases).Serum SAA,CRP,peripheral NLR,PLR and humoral immunity parameters were compared.Pearson correlation was used to analyze the correlation of serum SAA,CRP,peripheral NLR,and PLR with humoral immune.Receiver operating characteristic(ROC)curves were plotted to analyze the diagnostic value of serum SAA,CRP,peripheral NLR,and PLR in severe mycoplasma pneumonia.Results Serum SAA,CRP,immunoglobulin M(IgM),peripheral NLR and PLR in the case group were significantly higher than those of the healthy control group,and the serum immunoglobulin A(IgA)was significantly lower(P<0.05).Serum SAA,CRP,IgA,IgM,peripheral NLR and PLR in the severe group were significantly higher than those of the mild group(P<0.05).Serum SAA,CRP,peripheral NLR and PLR were positively correlated with serum IgA and IgM in children with mycoplasma pneumoniae pneumonia(r=0.640,0.418,0.611,0.483,0.527,0.428,0.553,and 0.541,respectively;P<0.05).The area under the curve(AUC)of SAA,CRP,NLR and PLR in the combined diagnosis of severe mycoplasma pneumoniae pneumonia was significantly higher than that of their single detection(P<0.05).The sensitivity of single detection of SAA and PLR and their combination in diagnosing severe mycoplasma pneumoniae pneumonia was significantly higher than that of CRP and NLR,and the sensitivity of NLR was significantly higher than that of CRP(P<0.05).The specificity of single detection of CRP and NLR and their combination in diagnosing severe mycoplasma pneumoniae pneumonia was significantly higher than that of SAA,and the specificity of CRP and the combination was significantly higher than that of NLR and PLR(P<0.05).Conclusion The occurrence and development of mycoplasma pneumoniae pneumonia change serum SAA,CRP,peripheral NLR,PLR and humoral immunity parameters.Serum SAA,CRP,peripheral NLR and PLR in children with mycoplasma pneumoniae pneumonia are significantly correlated with humoral immunity.The combination of serum SAA,CRP,peripheral NLR and PLR offers a better diagnostic value for severe mycoplasma pneumoniae pneumonia.
mycoplasma pneumoniae infectionserum amyloid AC-reactive proteinneutrophil to lymphocyte ratioplatelet to lymphocyte ratiohumoral immunity
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维普
