Objective To analyze the expression levels of programmed cell death ligand-1(PD-L1)and proliferating cell nuclear antigen-67(Ki-67)in endometrial carcinoma(EC)tissues,and to explore their clinical significances.Methods A total of 110 EC tissues were collected from EC patients who underwent surgical treatment in our hospital from January 2022 to August 2023.Based on the tumor-node-metastasis(TNM)staging,they were assigned into group A(stage Ⅰ,n=25),group B(stage Ⅱ,n=41),group C(stage Ⅲ,n=31)and group D(stage Ⅳ,n=13).The positive expressions of PD-L1 and Ki-67 in EC tissues of the four groups were detected by immunohistochemistry.Their clinical significances in EC patients were analyzed.Results There were no significant differences in the baseline data among the four groups(P>0.05).The serum cancer antigen 125(CA-125),carbohydrate antigen 19-9(CA19-9)and positive expression rates of PD-L1 and Ki-67 in group D were significantly higher than those of group A,B and C,with significant differences in pairwise comparisons(P<0.05).The Kendall's tau-b correlation analysis showed that the positive expressions of PD-L1 and Ki-67in EC tissues,and serum CA-125 and CA19-9 were positively correlated with clinical staging of EC(Ther values were 0.314,0.354,0.306,0.392,respectively,P<0.05).The ordered Logistic regression analysis showed that with the reference of stageⅠEC tissues,the decreases in the positive expression rates of PD-L1 and Ki-67 were significantly correlated with the increased risk of advanced tumor staging by 0.145 times and 0.320 times,respectively(P<0.05).Serum CA-125 and CA19-9 levels were significantly correlated with tumor staging of EC(OR>0.05,P<0.05).Conclusion Positive expression rates of PD-L1 and Ki-67 are abnormally altered in EC tissues,which are correlated with tumor staging of EC.
endometrial carcinomaclinical stageprogrammed cell death ligand-1proliferating cell nuclear antigen-67
万方数据
维普
