Clinical study of diffusion tensor imaging in the evaluation of cognitive function of cerebral infarction patients treated with butylphthalide sodium chloride
Objective To explore the clinical application of diffusion tensor imaging(DTI)in the evaluation of cognitive function in cerebral infarction patients treated with butylphthalide sodium chloride.Methods Forty patients with cerebral infarction admitted to our hospital from January 2021 to December 2022 were randomly assigned into group A(n=20)and group B(n=20).Routine symptomatic treatment and intravenous thrombolytic therapy using recombinant tissue plasminogen activator(rt-PA)were performed in both groups.Butylphthalide sodium chloride was additionally given to patients of group B.DTI was performed before and after treatment in both groups.The curative effect,fibrinolytic indicators,neurological deficits,cognitive function level and DTI data were observed in the two groups.Results The clinical efficacy of group B was significantly higher than that of group A(P<0.05).After treatment,serum D-dimer(D-D),plasma plasminogen activator inhibitor type 1(PAI-1),and plasma fibrinogen(FIB)levels were significantly reduced in both groups,which were significantly lower in group B than those of group A(P<0.05).Significantly reduced National Institute of Health Stroke Scale(NIHSS)score and elevated Montreal Cognitive Assessment Scale(MoCA)score were observed in both groups after treatment,which were more pronounced in group B than those of group A(P<0.05).The fractional anisotropy(FA)in DTI was elevated after treatment in both groups,which was more pronounced in group B than that of group A(P<0.05).Conclusion Intravenous thrombolytic therapy using rt-PA combined with butylphthalide sodium chloride is effective in the treatment of cerebral infarction,which is helpful to improve the neurological and cognitive functions.DTI can effectively evaluate the changes of cognitive function,showing a positive role in predicting the prognosis.
diffusion tensor imagingbutylphthalide sodium chloridecerebral infarctioncognitive function
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