Correlation between serum SAMD9L level and macrophage-related cytokines in patients with active pulmonary tuberculosis
Objective To explore the application value of serum sterile-alpha motif domain containing 9-like protein(SAMD9L)and macrophage related cytokines in the diagnosis of active pulmonary tuberculosis(APTB)patients.Methods In this retrospective study,totally 84 patients with APTB,84 patients with latent tuberculosis infection(LTBI)and 84 healthy volunteers,who visited our hospital from May 2019 to May 2022,were enrolled.The expression levels of serum SAMD9L,inducible nitric oxide synthase(iNOS),and arginase-1(Arg-1)among three groups were detected,the correlation of the expression levels of serum SAMD9L,iNOS,and Arg-1 were analyzed by using Pearson method,multivariate Logistic regression model was applied to analyze the influencing factors of APTB,and receiver operating characteristic(ROC)was used to assess the predictive value of SAMD9L,iNOS and Arg-1 for APTB.Results The levels of SAMD9L and Arg-1 in APTB group were obviously higher than those of LTBI group and control group(P＜0.05),but iNOS level was obviously lower(P＜0.05).The level of iNOS was negatively correlated with the levels of SAMD9 L and Arg1(r=0.405,0.585,respectively;P＜0.05),while SAMD9L level was positively correlated with Arg-1 level(r=0.416,P＜0.05).Logistic regression showed that iNOS was a protective factor for APTB patients(P＜0.05),while SAMD9L and Arg-1 were risk factors for APTB patients(P＜0.05).The combined diagnosis of SAMD9L,iNOS,and Arg-1 for APTB was superior to any single diagnosis(Z combination SAMD9L=1.730,Z combination-iNOS=2.839,Z combination-Arg-1=2.086;P＜0.05).After six months of treatment,the expression levels of serum SAMD9L and Arg-1 decreased,while the expression of iNOS increased(P＜0.05).Conclusion The expression levels of serum SAMD9L and Arg-1 of APTB patients are up-regulated,with closely associated with macrophage-related cytokines.The combined detection of the three has clinical significance for the diagnosis of APTB.
NETL
NSTL
万方数据
