Changes in the serum 25 hydroxyvitamin D levels in patients with lumbar disc herniation at high altitude and the clinical significance
Objective To investigate the changes in serum 25 hydroxyvitamin D(25-OH-D)levels in patients with lumbar disc herniation(LDH)at high altitude and the clinical significance.Methods Two hundred LDH patients at high altitude who were initially treated in our hospital from August 2021 to July 2022 were selected as the study group,and another age-matched 100 healthy volunteers during the same period were selected as the control group.The general data and serum 25-OH-D level of the two groups were compared,and the serum 25-OH-D levels of LDH patients with different clinical characteristics in the study group were compared.The correlation between serum 25-OH-D levels and clinical characteristics in LDH patients was assessed.The efficacy of the study group was evaluated after 3 months of treatment,and the factors influencing the efficacy of patients with primary LDH were analyzed.Post-treatment serum 25-OH-D levels of LDH patients with different efficacies were compared,and the correlation between post-treatment serum 25-OH-D levels and efficacy was analyzed.Results Serum 25-OH-D in the study group was significantly lower than that of the control group(P＜0.05).Serum 25-OH-D in the study group was negatively correlated with the severity of the disease and the degree of intervertebral disc degeneration(r=-0.527 and-0.584,respectively;P＜0.05).Univariate analysis showed that age,body mass index(BMI),severity of disease,degree of intervertebral disc degeneration,and pre-treatment serum 25-OH-D levels were significantly correlated with the efficacy of patients with primary LDH(P＜0.05).Multifactorial analysis showed that age,BMI,and serum 25-OH-D level before treatment were factors influencing the efficacy of patients with primary LDH(P＜0.05).Serum 25-OH-D levels after 1 month,2 months,and 3 months of treatment were significantly higher in patients with good efficacy than those with poor efficacy,which were positively correlated with the efficacy(r=0.468,0.491 and 0.523,respectively;P＜0.05).Conclusion Serum 25-OH-D levels in LDH populations at high altitudes decrease,which are closely correlated with the severity of disease and intervertebral disc degeneration.
high altitudelumbar disc herniation25 hydroxyvitamin Dintervertebral disc degenerationseverity of disease
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