Effect of sivelestat sodium combined with ulinastatin on inflammatory response and blood gas in patients with acute respiratory distress syndrome
Objective To detect the effect of sivelestat sodium combined with ulinastatin on inflammatory response and blood gas in patients with acute respiratory distress syndrome(ARDS).Methods A total of 202 ARDS patients admitted in our hospital from May 2021 to March 2023 were enrolled.According to the coin toss methods,patients were assigned into group A(n=101,treatment of ulinastatin)and group B(n=101,treatment of sivelestat sodium combined with ulinastatin).Vital signs(blood pressure,heart rate,body temperature,respiration),inflammatory response(procalcitonin[PCT],lipopolysaccharide[LPS],lysosomal enzyme[LE]),blood gas(oxygenation index[PaO2/FiO2],blood lactic acid[Lac],active carbonic anhydrase[CA]),pulmonary function(dynamic lung compliance[Cdyn],positive end expiration pressure[PEEP],airway resistance[Raw])and adverse events were compared between groups.Results After treatment,significantly decreased heart rate,temperature and respiratory rate,and significantly increased blood pressure were detected in both groups(P＜0.05).No significant differences in the vital signs after treatment were detected between groups(P＞0.05).PCT,LPS,LE,Lac,PEEP and Raw were significantly decreased in both groups after treatment,which were significantly lower in group B than those of Group A(P＜0.05).PaO2/FiO2,CA and Cdyn were significantly increased in both groups after treatment,which were significantly higher in group B than those of Group A(P＜0.05).No significant difference in the incidence of adverse events was detected between groups(P＞0.05).Conclusion Sivelestat sodium combined with ulinastatin offers an excellent therapeutic efficacy on ARDS,which greatly improve vital signs,inflammatory response,blood gas and pulmonary function.
sivelestat sodiumulinastatinacute respiratory distress syndromeblood gas parameters
NETL
NSTL
万方数据
