Effects of the cluster management strategy on immune function and prognosis of sepsis patients
Objective To analyze the effects of the cluster management strategy on immune function and prognosis of sepsis patients.Methods Eighty-two sepsis patients admitted to our hospital between April 2022 and April 2023 were selected as the study subjects.They were assigned into the control group(No.1-41)and the observation group(No.42-82)according to the sequence of admission.All patients received conventional treatments and interventions,and those in the observation group additionally received cluster management strategy.Immune function indicators,inflammatory indicators,hemodynamic indicators,and prognostic effects between the two groups were compared.Results After the intervention,CD4+and CD4+/CD8+levels in the observation group were significantly higher than those of the control group(P＜0.05),while CD8+level and white blood cell count(WBC)were significantly lower(P＜0.05).After the intervention,interleukin 6(IL-6),C-reactive protein(CRP)and procalcitonin(PCT)levels significantly decreased in both groups than those before the intervention,which were significantly lower in the observation group than those of the control group(P＜0.05).The heart rate(HR)of the observation group was significantly lower than that of the control group(P＜0.05),while the mean arterial pressure(MAP)and central venous pressure(CVP)were significantly higher(P＜0.05).The use time of vasoactive drugs,duration of mechanical ventilation and total hospitalization time in the observation group were significantly shorter than those of the control group(P＜0.05).Conclusion The cluster management strategy can achieve significant intervention effects on sepsis patients,which can effectively improve immune function,reduce inflammatory factors,stabilize hemodynamics,and promote the prognosis.
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