Effects of intravitreal injection of leizumab on visual acuity,serum GAS6,SDF-1 and VEGF in patients with proliferative diabetic retinopathy
Objective To investigate the effects of intravitreal injection of leizumab on visual acuity,serum growth arrest-specific protein 6(GAS6),human stromal cell-derived factor-1(SDF-1)and vascular endothelial growth factor(VEGF)in patients with proliferative diabetic retinopathy(PDR).Methods A total of 82 patients with PDR admitted to our hospital from January to December 2022 were included,and they were divided into observation group(n=41)and control group(n=41)by a random number table.The patients in the control group were treated with pars plana vitrectomy(PPV),while those in the observation group were additionally treated with preoperative intravitreal injection of leizumab before PPV.The therapeutic effects of the two groups were compared,including the visual acuity and intraocular pressure of the two groups before and 1 week after surgery,the changes in serum GAS6,SDF-1 and VEGF levels between the two groups before surgery and 1 week after surgery,and the occurrence of postoperative complications between the two groups.Results The total effective rate of observation group was significantly higher than that of control group(95.12％vs 78.05％,P＜0.05).The levels of intraocular pressure,serum GAS6,SDF-1 and VEGF 1 week after surgery in the both groups were significantly decreased than those before surgery,which in observation group were significantly lower than those of control group(P＜0.05).The visual acuity on 1 week after surgery of the two groups was significantly higher than that before surgery,and which was significantly higher in the observation group than in the control group on 1 week after surgery(P＜0.05).The total incidence of postoperative complications in observation group was significantly lower than that of control group(4.88％vs 24.39％,P＜0.05).Conclusion The intravitreal injection of leizumab assisted PPV in the treatment of PDR has satisfactory effects,which can significantly improve the visual acuity of patients,and reduce intraocular pressure.In addition,it is capable to reduce serum levels of GAS6,SDF-1 and VEGF,and the incidence of postoperative complications.It is worth of promotion.
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