Prognostic values of serum miR-140-5p and SFRP-5 for in-stent restenosis in diabetes patients combined with coronary heart disease after percutaneous coronary intervention
Objective To investigate the predictive values of serum microRNA-140-5p(miR-140-5p)and secreted frizzled related protein 5(SFRP-5)for in-stent restenosis(ISR)in diabetes patients combined with coronary heart disease after percutaneous coronary intervention(PCI).Methods A total of 125 diabetes patients combined with coronary heart disease after PCI admitted to our hospital from May 2021 to May 2022 were retrospectively recruited.According to the results of coronary angiography(CAG)after 12 months of follow-up,patients were assigned into ISR group(41 cases)and non-ISR group(84 cases).Expression levels of serum miR-140-5p and SFRP-5 were compared between the two groups and patients with varying severities.Receiver operating characteristic(ROC)curves were drawn to analyze the predictive value of serum miR-140-5p and SFRP-5 in ISR after PCI,and the related risk factors affecting ISR after PCI were analyzed.Results Serum miR-140-5p and SFRP-5 in ISR group were significantly lower than those of non-ISR group(all P＜0.01).Serum miR-140-5p and SFRP-5 in mild diabetes group were significantly higher than those of severe diabetes group(all P＜0.01).Serum miR-140-5p and SFRP-5 in mild coronary disease group were significantly higher than those of moderate and severe groups,which were significantly higher in moderate coronary disease group than the severe coronary disease group(all P＜0.01).ROC curves showed that the sensitivity of serum miR-140-5p,SFRP-5 and their combination in predicting ISR after PCI was 80.87％,84.24％and 94.17％,respectively,and the specificity was 70.33％,82.17％and 89.52％,respectively(all P＜0.01).The area under the curve(AUC)of serum miR-140-5p,SFRP-5 and their combination was 80.87,84.24 and 94.17,respectively(all P＜0.01).The optimal cut-off values for miR-140-5p and SFRP-5 were 0.91 ng/mL and 33.82 μg/L,respectively.Logistic regression analysis showed that family history of coronary heart disease,elevated levels of low-density lipoprotein cholesterol(LDL-C)and hemoglobin A1C(HbA1c),elevated levels of systolic and diastolic blood pressure,number of stents ≥ 3,stent diameter＜3 mm,and presence of series stents were all risk factors for ISR after PCI(all P＜0.05).Use of itolizumab,and increased levels of SFRP-5 and miR-140-5p were independent protective factors for ISR after PCI(all P＜0.05).Conclusion Serum miR-140-5p and SFRP-5 have a certain correlation with the severity of coronary heart disease combined with diabetes,and their combined detection has a high predictive value for the occurrence of ISR after PCI.Dynamic monitoring of miR-140-5p and SFRP-5 is helpful to prevent the occurrence of ISR.
serum microRNAsecreted frizzled related protein 5coronary heart diseasediabetesin-stent restenosis
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